OBJECTIVE Although cumulative evidence suggests that increased oxidative stress may lead to insulin resistance in vivo or in vitro, community-based studies are scarce. This study examined the longitudinal relationships of oxidative stress biomarkers with the development of insulin resistance and whether these relationships were independent of obesity in nondiabetic young adults. RESEARCH DESI...

Background: The purpose of the present investigation was to study the possible differences between young and elderly individuals regarding muscle damage, position sense, and oxidative stress biomarkers in response to resistance eccentric-biased exercise. Methods: Ten young and 10 elderly individuals performed a bout of resistance exercise (i.e., squat exercise). Muscle damage indices (i.e., iso...

Objective: The present study was intended to examine whether administration of aqueous extract of the leaves of Ocimum sanctum L. (Tulsi) do possess a protective effect against cadmium-induced oxidative stress in rat heart. Methods: Male albino rats were divided into four groups; control, cadmium treated, aqueous extract protected and only aqueous extract treated (positive control). The rats we...

Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants. We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans. There...

Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated ...

Oxidative stress is the imbalance between production of reactive oxygen species (ROS) and ability of the biological systems to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell including proteins, lipi...

Acute strength exercise elicits a transient oxidative stress, but the factors underlying the magnitude of this response remain unknown. The purpose of this investigation was to determine whether muscle-fiber type relates to the magnitude of blood oxidative stress after eccentric muscle activity. Eleven college-age men performed 3 sets of 50 eccentric knee-extensions. Blood samples taken pre-, p...

Oxidative stress is involved in chronic and acute pathologies: cardiovascular, neurodegenerative, neoplastic, inflammatory and infectious diseases. Clinical trials focused on prevention of cardiovascular and neoplastic diseases involving antioxidant supplementation have however provided predominantly negative obserations in large-scale studies. Screening of patient cohorts to assess baseline ox...

Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration diabetic retinopathy, have their origin in the posterior segment of eye, making physiopathology both complex interconnected. In addition to age factor, these diseases share same mechanism disorder based essentially on oxidative stress. this context, imbalance between...

This review article is intended to describe how oxidative stress regulates cardiovascular disease development and progression. Epigenetic mechanisms related to oxidative stress, as well as more reliable biomarkers of oxidative stress, are emerging over the last years as potentially useful tools to design therapeutic approaches aimed at modulating enhanced oxidative stress "in vivo", thereby mit...