background: the aim of this study was to investigate the effects of leishmania major infection on the induction of oxidative stress in skin and lung of female mice. methods: balb/c mice were randomly divided into the control and experi-mental groups. the experimental groups were subcutaneously infected with in-oculums promastigotes of l. major . the animals were sacrificed at 20, 40, 60, 90 and...

this study was conducted to evaluate the cytoprotection of various extracts and bioactive compounds found in pistacia vera againts cytotoxicity, ros formation, lipid peroxidation, protein carbonylation , mitochondrial and lysosomal membrane damages in cell toxicity models of diabetes related carbonyl (glyoxal) and oxidative stress (hydroperoxide). methanol, water and ethyl acetate were used to ...

conclusions despite the presence of vast oxidative stress in hepatitis b, antioxidant therapy is not always effective as a treatment strategy, especially considering that antioxidants can act as “double-edged swords” or antioxidants; if not used at the right time or place or in the right combination, these substances can easily become pro-oxidants. therefore, several studies will be needed to d...

abstract background and objective: it has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. materials and methods: twenty male ...

conclusions lead contamination in the presence of an emf exacerbates the oxidative damage to plasma proteins as well as the conformational changes in hb. an artificial neural network can be used as a predictive tool for the oxidative danger posed to workers in industrial fields, battery manufacturing companies, and power plants. patients and methods in this experimental study, the blood samples...

objective(s): nanotechnology and nanoparticles are increasingly recognized for their potential applications in aerospace engineering, nanoelectronics, and environmental remediation, medicine and consumer products. more importantly is the potential for the application of silver nanoparticles (ag nps) in the treatment of diseases that require maintenance of circulating drug concentration or targe...

objectives: curcumin has anti-inflammatory and antioxidative properties. the objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (i/r). materials and methods: animals were randomly divided into 9 groups. the groups with 24-h reperfusion consisted of sham-24h,...

mycophenolate mofetil (mmf) is a selective inhibitor of inosine-5′-monophosphate dehydrogenase. gastrointestinal (gi) disturbances in immature ones are reported for mmf-induced compilations, which in the case of occurrence dose reduction is required. thus, in the present study, the fructooligosaccharide raftilose® (rft) was co-administrated with mmf to estimate the protective effect of rft agai...

nigella sativa (ns) ( ranunculaceae ) used as a protective and therapeutic traditional medicine. this study evaluates the effect of ns on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. fifty male wistar rats were divided into five groups: (1) control; (2) lipopolysaccharide (lps), 1 mg/kg/day; (3) lps + ns (hydroalcohol...

increased serum uric acid is known to be a major risk related to the development of several oxidative stress diseases. the aim of this study was to investigate the effect of parsley, quercetin and kaempferol on serum uric acid levels, liver xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration) in norma...