In the present study, we report the interaction of an artificial oligolysine (referred to as AOL) realized in our laboratory with targets of biomedical importance. These included polyinosinic acid (poly rI) and its complex with polycytidylic acid (poly I:C), RNAs with well-known interferon-inducing ability, and double-stranded (ds) DNA. The ability of the peptide to bind both single-stranded po...

The first total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A have been accomplished using a nickel-catalyzed cross coupling of alkyl bromide with vinyl stannane as the final step. The other key steps include late-stage C(sp)–H bromination, the oxidative cleavage of a diol to provide the requisite ketone and ester for schilancidilactones A and...

The first total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A have been accomplished using a nickel-catalyzed cross coupling of alkyl bromide with vinyl stannane as the final step. The other key steps include late-stage C(sp3)-H bromination, the oxidative cleavage of a diol to provide the requisite ketone and ester for schilancidilactones A an...

Among the aromatic ketones, aceto phenone and its various substituted derivatives have been studied since early 20 century. This ketone can perform the self condensation reaction and produces trimmer having an aromat ic ring of 1,3,5-triphenyl benzene (T.P.B) with general fo rmula of C24H18. In this research, the compounds 1,3,5-triphenyl benzene and 1,3,5-tris (2-naphthyl) benzene are synthesi...

Abstract In this work, new bio-based copoly(ester amide)s were synthesized by a two-step melt polycondensation process, using 2,5-furanedicarboxylic acid dimethyl ester (DMFDC), 1,3-propanediol (PDO), and 1,3-diaminopropane (DAP), with different DAP content. The chemical structure of the obtained poly(trimethylene 2,5-furandicarboxylate)-co-poly(propylene furanamide) (PTF-co-PPAF) copolymers wa...

Theories of browning reactions, including carbonyl-amino, caramelization, and oxidative types, are integrated in review. A unified mechanism for browning in sugaramine systems is presented, wherein sugaramine condensation, the Amadori rearrangement, sugar dehydration by β-elimination reactions, and reductone formation are shown to be important intermediary reactions leading to the production of...

Escherichia coli Dps (DNA-binding proteins from starved cells) is the prototype of a DNA-protecting protein family expressed by bacteria under nutritional and oxidative stress. The role of the lysine-rich and highly mobile Dps N-terminus in DNA protection has been investigated by comparing the self-aggregation and DNA-condensation capacity of wild-type Dps and two N-terminal deletion mutants, D...

Sesquiterpene lactones (SLs) are a group of secondary metabolites that represent a diverse and unique class of natural products and are important constituent of essential oils, formed from head-to-tail condensation of three isoprene units and subsequent cyclization and oxidative transformation to produce a cis or trans-fused lactone. In this editorial we are going to focus on anticancer, anti-i...

Poly(ADP-ribose)polymerases (PARPs) are a family of NAD+ consuming enzymes that play a crucial role in many cellular processes, most clearly in maintaining genome integrity. Here, we present an extensive analysis of the alteration of mitochondrial morphology and the relationship to PARPs activity after oxidative stress using an in vitro model of human hepatic cells. The following outcomes were ...