Background: Simultaneous exposure to noise and organic solvents such as styrene is an indispensable part of today’s industries. Numerous studies were done related to ototoxic effects of co-exposure to noise and styrene while some evidences showed the adverse effects of such exposure on other organs. In this study, we aimed to assess the subacute effects of combined exposure to noise and s...

Objective(s): Acute lung injury (ALI) has a high mortality rate and is characterized by damage to pulmonary system giving rise to symptoms such as histological alteration, lung tissue edema and production of proinflammatory cytokine. p-Coumaric acid (p-CA), as a phenolic compound, that is found in many types of fruits and vegetables has been reported to exhibit a thera...

conclusions in sum, the results indicate that the consumption of vitamin c can decrease the lipid peroxidation and increase the level of tac, and is ineffective on enzyme and non-enzyme antioxidants and muscle damage. objectives the aim of the present research was to study the effect of endurance swimming training with the consumption of a vitamin c supplement on indices of oxidative stress and...

plant growth is often limited by low levels of soil micronutrients such as copper (cu), ‎especially in calcareous salt-affected soils of arid and semiarid regions. the aim of this ‎work was to investigate individual and combined effects of salinity and cu on growth, leaf ‎relative water content (lrwc), cell membrane permeability, lipid peroxidation, and total ‎phenolic content (tpc) of rosemary...

background: cadmium (cd) is a heavy metal which is widely spread in our surroundings and has a very strong ability to accumulate in the body organs such as spleen. in this study we aimed to determine the genotoxicity and cytotoxicity effects on mice spleen  treated with cadmium. methods: thirty male mice were enrolled in this study and kept in standard conditions. mice were randomly divided int...

OBJECTIVE To evaluate oxidative damage (lipid oxidation, protein oxidation, thiobarbituric acid-reactive substances [TBARS], and carbonylation) and inflammation (expression of phosphorylated AMP-activated protein kinase and mammalian target of rapamycin [p-AMPK and p-mTOR, respectively]) in the lung parenchyma and diaphragm muscles of male C57BL-6 mice exposed to cigarette smoke (CS) for 7, 15,...

Melatonin is a free radical scavenger and a broad-spectrum antioxidant and has well-documented immunomodulatory effects. We studied the effects of this hormone on lung damage, oxidative stress, and inflammation in a model of ventilator-induced lung injury (VILI), using 8- to 12-wk-old Swiss mice (n = 48). Animals were randomized into three experimental groups: control (not ventilated); low-pres...

Large cohort studies in the U.S. and in Europe suggest that air pollution may increase lung cancer risk. Biomarkers can be useful to understand the mechanisms and to characterize high-risk groups. Here we describe biomarkers of exposure, in particular DNA adducts as well as markers of early damage, including mutagenicity, other endpoints of genotoxicity and molecular biomarkers of cancer. Sever...

Lung cancer rates among men and particularly among women, almost all of whom are non-smokers, in Xuan Wei County, China are among the highest in China and have been causally associated with exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). As such, this population provides a unique opportunity to study the pathogenesis of PAH-induc...