Buah Merah, a typical fruit from Papua, Indonesia which is used empirically in cancer therapy rich carotenoids and flavonoids. However, the mechanisms by Merah ameliorates remained unknown. Natural antioxidant enzymes pro-oxidant modulation significantly suppressed ROS production growth. Therefore, determination of target contents was studied through an silico approach. Carotenoid flavonoid com...

BACKGROUND Oxidative stress is recognized to be one of predisposing factor in the pathogenesis of COPD. The oxidant/antioxidant imbalance is significantly pronounced in patients with COPD exacerbation. N-acetylcysteine (NAC) seems to be able to reduce COPD exacerbations by modulating the oxidative stress in addition to its well-known mucolytic activity, but there are discordant findings on the ...

Arbogast, Sandrine, and Michael B. Reid. Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide. Am J Physiol Regul Integr Comp Physiol 287: R698–R705, 2004. First published June 3, 2004; 10.1152/ ajpregu.00072.2004.—Free radicals are produced continuously by skeletal muscle fibers. Extracellular release of reactive oxygen species (RO...

Neutrophil-related, oxidant-mediated injury to the pulmonary microvasculature appears to follow endotoxemia, cutaneous thermal injury, and ischemia-reperfusion injury to the liver or intestine. Glutathione is an important endogenous intracellular oxygen radical scavenger. Plasma concentrations of oxidized glutathione (GSSG) reflect oxidant injury resulting from an overdose of certain oxidativel...

Oxidative stress affects clinical outcome in patients with ST-elevation acute coronary syndrome (STE-ACS). Although high-density lipoprotein (HDL) particles are generally considered protective, deleterious properties of HDL have been observed in patients with acute myocardial infarction. Here, we analysed the association between pro-oxidant HDL and all-cause mortality in STE-ACS patients. We de...

Article history: Received 25 November 2015 Accepted 25 November 2015 Available online 2 December 2015 disease while strikingly there was no signal in subjects without diabetes. These findings, supported by independent studies (Mohammedi et al., 2015), suggest that some individuals have a genetically-driven impairment of anti-oxidant defenses that predispose them to cardiovascular disease in sta...

Potentially damaging species (reactive oxygen, nitrogen and chlorine species) arise as by-products of metabolism and as physiological mediators and signalling molecules. Levels of these species are controlled by the antioxidant defence system. Several components of this system are micronutrients (e.g. vitamins C and E) or are dependent upon dietary micronutrients (e.g. CuZn and Mn superoxide di...

Kinsey GR, McHowat J, Beckett CS, Schnellmann RG. Identification of calcium-independent phospholipase A2 in mitochondria and its role in mitochondrial oxidative stress. Am J Physiol Renal Physiol 292: F853–F860, 2007. First published October 17, 2006; doi:10.1152/ajprenal.00318.2006.—Oxidant-induced lipid peroxidation and cell death mediate pathologies associated with ischemiareperfusion and in...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by the loss of NADPH and enhanced erythrocyte oxidant sensitivity. Historically, it has been theorized that the elevated oxidant sensitivity of G6PD-deficient erythrocytes arises as the direct consequence of decreased intracellular glutathione (GSH) concentrations. To directly investigate the basis of G6PD deficiency oxidant s...

In this study, we show that superoxide production is carried out within intracellular compartments of human neutrophils and not at the plasma membrane following stimulation with phorbol myristate acetate. Oxidant production was not observed in unstimulated cells. Stimulated cells exhibited superoxide production in two distinct types of intracellular organelles. Initially, activity was detected ...