575 IntroductIon Anti-epileptic medications can be divided into two major groups. The traditional antiepileptic drugs, which were released for use prior to 1978, are Phenobarbital, Phenytoin, Primidone, Clonazepam, Ethosuximide, Carbamazapine and Valproate. There was a 15-year period from 1978 to 1993, when no new antiseizure drug was approved for use. Since 1993, an additional eight new anti-e...

Materials and methods Our research took place in a private psychiatric clinic (2005-2009) and focused on the effectiveness of a certain pharmacological combination administered to a sample of 37 patients, in an attempt to control the alcohol withdrawal syndrome. The pharmacological combination comprised 30mg-60mg Chlordiazepoxide hydrochloride, 300mg-500mg Triapride hydrochloride, 300mg-500mg H...

Allergic reactions to antiepileptic drugs in the form of skin rash are not uncommon but angioedema, an acute life threatening reaction is rare. Angioedema has been reported with the use of oxcarbazepine and carbamazepine. We report a case of a 33-year-old woman with focal epilepsy who developed angioedema following levetiracetam monotherapy. The patient had previous skin rashes with both phenyt...

background the prevalence of epilepsy in the elderly is more than other age groups and treatment of epilepsy in this group is challenging for neurologists. the purpose of this study is to compare the efficacy and safety of phenytoin versus oxcarbazepine in the elderly patients with newly diagnosed secondary generalized seizure. material and methods we enrolled 142 elderly patients with epilepsy...

PURPOSE To determine the influence of indapamide on the protective action of numerous conventional and second-generation antiepileptic drugs (carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, topiramate and valproate) in the mouse maximal electroshock seizure model. MATERIAL AND METHODS Electroconvulsions were evoked in Albino Swiss mice by a current (sine-wave, 0.2 s stimulus duratio...

The occurrence of bi-directional drug interactions between antiepileptic drugs (AEDs) and combined oral contraceptives (OCs) pose potential risks of un-intended pregnancy and as well as seizure deterioration. It is well established that several of the older AEDs (carbamazepine, phenytoin and phenobarbital), are strong inducers of the hepatic cytochrome P450 (CYP) 3A4 enzyme system, and are asso...