The interplay among pain, allergy and dysregulated inflammation promises to yield significant conceptual advances in immunology and chronic pain. Hapten-mediated contact hypersensitivity reactions are used to model skin allergies in rodents but have not been utilized to study associated changes in pain perception in the affected skin. Here we characterized changes in mechanical hyperalgesia in ...

Inosine, a naturally occurring purine formed from the breakdown of adenosine, has recently been shown to exert powerful anti-inflammatory effects both in vivo and in vitro. This study evaluated inosine as a potential therapy for colitis. Colitis was induced in mice by the administration of dextran sulfate sodium (DSS). Oral treatment with inosine was begun either before the onset of colitis or ...

â  the adverse effects of non-steroidal anti-inflammatory drugs (nsaids) on the upper gastrointestinal (gi) tract and small intestine are well established. the effect of such therapy on the large intestine, so called nsaid-induced colopathy, is less well described. nsaid-induced colopathy usually involves the right colon due to a higher concentration of the drug at this site, but the rectum may...

objective: the aim of this study was to determine the protective effects of coriandrum sativum on acetic acid-inducedcolitis in rats. c. sativum (coriander) has long been used in iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations.  materials and methods: colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fa...

Chronic inflammatory bowel disease is characterised by an up-regulation of the synthesis and release of a variety of pro-inflammatory mediators leading to excessive tissue injury. Flavonoids are able to inhibit enzymes and/or due to their antioxidant properties regulate the immune response. The goal of the present study was to evaluate the mechanisms of action of phenolic compounds present in g...

Objective: The aim of this study was to determine the protective effects of Coriandrum sativum on acetic acid-inducedcolitis in rats. C. sativum (Coriander) has long been used in Iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations.  Materials and Methods: Colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fa...

Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by pruritus and eczematous lesions. It has been described that the repeated topical application of hapten oxazolone to ears sensitized mice cause lesions mimic some features AD. However, in most published reports number challenges significantly high (6 12), which translates into long duration assay causing s...

The ring oxidation of 2H-oxazole, or C2-unsubstituted oxazole, to 2-oxazolone, a cyclic carbamate, was observed on various 4- or 5-substituted oxazoles. Using 5-(3-bromophenyl)oxazole as a model compound, its 2-oxazolone metabolite M1 was fully characterized by liquid chromatography/tandem mass spectrometry and nuclear magnetic resonance. The reaction mainly occurred in the liver cytosolic frac...

Abstract Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, dysregulated host responses to microbial stimulation. Strategies that target microbiota have emerged as potential therapies and, of these, probiotics gained greatest attentio...