Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Gene...

BACKGROUND The aim of the present study was to characterize the morphological and ultrastractural of mouse ovarian tissue with different cryoprotectant solution. OBJECTIVE Aim of this study, is to demonstrae an improved convetional vitrification method on mouse ovarian tissue using different concentrations of ethylene glycol (EG) and/or dimetyl sulfoxide (DMSO) and EG. MATERIALS AND METHODS...

BACKGROUND Cryopreservation of mammalian ovaries has been reported with different levels of success. Cryopreservation of ovarian tissue may be a potential alternative for treatment of infertility and many attempts have been done to improve the efficiency of ovarian cryopreservation. The objective of the present study was to compare the direct cover vitrification (DCV) with ethylene glycol (EG),...

BACKGROUND Anti-Müllerian hormone (AMH) inhibits the initiation of the development and early growth of mouse ovarian follicles. Furthermore, the ovarian follicle pool diminishes prematurely in AMH-knockout mice. In this study, we examined whether AMH plays a similar role in humans, controlling ovarian follicle growth. METHODS Human ovarian cortical tissue biopsy specimens were cut into small ...

BACKGROUND Depletion of ovarian follicles is associated with the end of reproductive function in ageing females. Recently, it has been described that this process parallels increases in the concentration of norepinephrine (NE) in the rat ovary. In sexually mature rats, experimentally-induced increases in the sympathetic tone of the ovary is causally related to ovarian cyst formation and derange...

In this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. The study comprised of three different groups of twenty one mice as follows: The first group (Group 100) which treated by gavage with copper sulfate at a dose of 100 mg kg-1 for 5 weeks. The second group (Group 200), whic...

Background: Ovarian torsion is an important gynecological emergency and various agents are used in the experimental phase to prevent ovarian injury. The aim of this study was determine effect granulocyte-colony-stimulating factor (G-CSF) use on ischemia/reperfusion injury torsion/detorsion model rat ovary. Methods: Twenty-eight Wistar-albino rats were randomly divided into four groups. first gr...

BACKGROUND A suitable culture system is important for follicle growth in adult bovine ovarian tissue. This study aimed to assess the avian chorioallantoic membrane (CAM) for short-term culture of adult bovine ovarian tissues compared with a traditional in vitro culture system. METHODS Ovarian cortical tissues (1-2 mm3), collected from slaughtered adult cows, were randomly assigned to control,...

background: diazinon (dzn) is an organophosphate insecticide widely utilized in agriculture all over the world and causes many negative effects on plants and animal species, especially on human. the aim of present study was to evaluate the effects of dzn on apoptosis of ovarian follicles in adult rats and to assess the protective role of vit e. methods: thirty adult female wistar rats were divi...