Objective Protein disulfide isomerase (PDI) is an oxidoreductase that is overexpressed in several cancers. PDI family members (PDIs) play a role in various diseases including cancer. Select PDIs were reported as useful markers in other cancers but their expression in ovarian cancer has not been thoroughly assessed. We sought to evaluate the expression of PDI, PDIA6, PDIR, ERp57, ERp72 and AGR3 ...

The aim of this review article was to evaluate the relationship and the possible etiological mechanisms between endometriosis, leiomyoma (LM) and adenomyosis and gynecological cancers, such as ovarian and endometrial cancer and leiomyosarcoma (LMS). MEDLINE was searched for all articles written in the English literature from July 1966 to May 2013. Reports were collected systematically and all t...

Primary ovarian carcinoma is a heterogeneous group of diseases and each subtype is characterized by distinct clinical, histologic, and molecular features. Ovarian cancers can be broadly subdivided into Type I and Type II tumors. This classification is not a histologic one, but describes tumorigenic pathways based on clinically correlated molecular data. Type I tumors include low-grade serous, l...

background: in vitro maturation (ivm) of immature oocytes collected from ovary has been proposed for fertility preservation. in addition, quality of oocytes post ivm is one of the factors determining its developmental competence. by using the non-invasive polscope system, both meiotic spindle (ms) and zona pellucida (zp) can be assessed in living oocytes. objective: the aim was to investigate t...

STUDY QUESTION Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? SUMMARY ANSWER In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian reserve and in 30% of patients, premature ovarian failure (POF) occu...

Received March 20, 2004; accepted May 28, 2004, Chinese Journal of Clinical Oncotgy Email: COCR~evou.com TelIFax): 86-22-2352-2919 OBJECTIVE Ovarian dysgerminoma is an uncommon ovarian malignancy. Its clinical features are special and there are many factors affecting its prognosis, tf treated properly, the patient can be cured. Otherwise it may endanger the patient's life. The aim of this study...

One of the most common skin diseases in women is mature acne. The mechanisms that are responsible for visible lesions still being recognized, and it impossible to put a single factor culpable development this dermatosis. aim article describe possible pathogenesis adult acne with description disorders occurring at level cells. main focus directed particular role endocrine system over 25 years ag...

Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It expressed in epithelial cells only and serves as regulator of various intracellular signaling pathways. As key player cell regulation, has been shown by research function mainly an oncogene cancers including breast cancer ovarian cancer. However, also reported be tumor suppressor types such colorectal A lot done about r...

background: previous studies have reported the antifertility activities of sulfonamides. this study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. methods: a total of 54 rats were randomly divided into 9 groups (n=6) . group i served as the control and group ii (vehicle) received saline. other groups, iii to ix,...