This year Molecular Genetics & Genomic Medicine (MGGM) turns 5 years old. For the editors of this journal it is time for some reflection, “looking back and looking forward”. The first issue appeared in May of 2013, 60 years after the publication by Watson and Crick’s discovery of the double-helical structure of DNA and 10 years after the completion of the Human Genome Project. The work for this...

The objectives of this study are to demonstrate the effect a function called ‘Chief Digital Office’ as responsible positioning digitization at C-level. This is intended show both importance measures and change projects with methodical approach in cross-sectional tasks for strategic work. previous work shows different functional layouts individual responsibilities without conceptual foundations ...

Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in mammals. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced-green fluorescent protein (EGFP) to perform visualized, whole-cell patch recordings from pre-pubertal female hypothalamic slices. The mouse POMC-EGFP neurons expressed the same endogenous conductance ...

Decisions are powerfully affected by anticipated regret, and people anticipate feeling more regret when they lose by a narrow margin than when they lose by a wide margin. But research suggests that people are remarkably good at avoiding self-blame, and hence they may be better at avoiding regret than they realize. Four studies measured people’s anticipations and experiences of regret and self-b...

This paper empirically analyzes sustainable relations between inward FDI (IFDI), outward (OFDI), the R&D expenditure ratio and CO 2 emissions based on balanced panel data from BRICS (namely, Brazil, Russia, India, China South Africa) countries for period 2003–2017. Generally, results confirm a negative effect of IFDI positive OFDI ratio, both with statistical significance. Further explo...

A slow outward current associated with spike frequency adaptation has been studied in the giant Aplysia neurons R2 and LP1. The current was observed during 60-s voltage clamp commands to potentials just below spike threshold. The slow outward current shows a marked voltage dependence at membrane potential less negative than -40 mV. The slow outward current is associated with increased membrane ...