The ideal biomaterials substitute for bone repair should possess the following characteristics: provide osteogenic, osteoinductive and osteoconductive properties; stimulate neo-angiogenesis process; absence of antigenic, teratogenic or carcinogenic reactions; avoid systemic toxicity complications; assure satisfactory support stability from mechanical properties point view; hydrophilic nature su...

Autologous bone remains the gold standard substitute in clinical practice. Therefore, microarchitecture of newly developed synthetic substitutes, which reflects spatial distribution materials scaffold, aims to recapitulate natural microarchitecture. However, is optimized obtain a mechanically stable, lightweight structure adapted biomechanical loading situation. In context application Triply Pe...

BACKGROUND Bone substitutes should have osteoconductive properties and be completely replaced with new bone with time. Adding collagen gel to prehydrated and collagenated porcine bone (PCPB) particles results in a sticky and moldable material which facilitates clinical handling. However, the possible influence of the gel on the bone tissue response is not known. PURPOSE The objective of the s...

We have developed a biodegradable composite scaffold for bone tissue engineering applications with a pore size and interconnecting macroporosity similar to those of human trabecular bone. The scaffold is fabricated by a process of particle leaching and phase inversion from poly(lactideco-glycolide) (PLGA) and two calcium phosphate (CaP) phases both of which are resorbable by osteoclasts; the fi...