A 28-year-old lady with end-stage renal failure on intermittent haemodialysis for 6 years complained of a constant right-sided chest pain. She was diagnosed to have Epstein syndrome in childhood characterized by macrothrombocytopathy, nephritis and sensory-neural deafness. The course of her renal failure was complicated by recurrent bleeding diathesis and poor compliance to medications leading ...

The widespread use of clhronic dialysis and renal homotransplantation, while prolonging the lives of patients with chronic renal failure, have concomitantly resulted in the appearance of severe disorders of calcium and phosphorus metabolism and disabling renal osteodystrophy (retardation of growth and dwarfism, osteitis fibrosa, rickets or osteomalacia and, at times, osteosclerosis). Furthermor...

Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease. The main two conditions are osteitis fibrosa, characterized by high bone turnover, increased osteoclastic and osteoblastic activity, and high levels of circulating parathyroid hormone (PTH) and adynamic bone disease characterized by low ...

Brown tumours (BT), an expression of osteitis fibrosa cystic due to primary hyperparathyroidism (pHPT), can occasionally be mistaken for malignancy. Among 615 patients who underwent parathyroidectomy for pHPT in our institution, the medical records of three patients affected by BT were reviewed. The first patient underwent surgical removal of the orbital mass for a suspected lachrymal gland neo...

Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron ac...

1 Yendt ER. In: Spittel JA, ed. Clinical Medicine. Endocrinology, vol 8. Philadelphia: Harper & Row, 1983;pp 11-23. 2 Mann JB, Alterman S, Hills AG. Albright's hereditary osteodystrophy comprising 'pseudohypoparathyroidism' and 'pseudopseudohypoparathyroidism'. Ann Intern Med 1 962;56:3 15-39. 3 Drezner M, Neelon FA, Lebovitz HE, et al. 'Pseudopseudohypoparathyroidism' type II. A possible defec...

Before the introduction of routine measurements of serum calcium in ambulatory services, PHTP (primary hyperparathyroidism) was symptomatic with classic bone disease (known as osteitis fibrosa cystica) nephrolithiasis, and acute neuropsychiatric syndrome with severe hypercalcemia. Currently, PHPT presents few unspecific symptoms. This cross-sectional study was conducted from December 1, 2007, t...

Clinical, biochemical, roentgenological, and histological features of slipped epiphyses (epiphysiolysis) in 11 out of 112 children with renal osteodystrophy have been analysed. Characteristic age-related patterns of involvement of different epiphyses are described. Quantitative measurements of iliac bone histology, serum parathyroid hormone levels, and clinical history show the presence of more...

A 49-year-old male with known history of end-stage renal disease (ESRD) presents with an intraoral exophytic mass of the right mandible. This lesion was given a histologic diagnosis of a Brown tumor. Purpose. To allow physicians to include this lesion in a differential diagnosis when evaluating patients with primary, secondary, or tertiary hyperparathyroidism.