Background Chronic mucocutaneous candidiasis (CMC) is a heterogeneous group of primary immunodeficiency diseases (PID) characterized by chronic and recurrent infections of the skin, nails, and oropharynx, mostly caused by Candida sp. CMC is often associated with autoimmune and endocrine disorders. However, CMC may be the only or the main phenotype in patients with AD IL-17F and AR IL-17RA defic...

Chronic mucocutaneous candidiasis (CMC) is a heterogeneous group of primary immunodeficiency diseases characterized by chronic and recurrent Candida infections of the skin, nails, and oropharynx. Gain-of-function mutations in STAT1 were very recently shown to be responsible for autosomal-dominant or sporadic cases of CMC. The reported mutations have been exclusively localized in the coiled-coil...

Objective To compare the incidence of oropharyngeal candidiasis (OC), or thrush, in renal transplant recipients receiving nystatin versus no antifungal prophylaxis. Methods This was a single-center, retrospective, non-inferiority study adult (RTRs) who received for 30 days OC prophylaxis (nystatin group) therapy (No PPX group). The primary outcome within 3 months post-transplant. Secondary outc...

Background: Fungal infections always occur in HIV patients due to depressed immunity. The most common fungal infections are candidiasis, cryptococcal meningitis and histoplasmosis. Objectives: To compare the efficacy and safety of the antifungal available for the three most common opportunistic fungal infections in HIV patients. Methods: The databases that we used to gather the information are ...

The conventional identification (assimilation profiles in the API 20C [bioMérieux Vitek, Inc., Hazelwood, Mo.] identification system, colony color on CHROMagar Candida [CHROMagar, Paris, France], and morphology on cornmealTween 80 agar) of 32 atypical isolates of Candida albicans recovered during a study of oropharyngeal candidiasis in human immunodeficiency virus-infected individuals could not...

INTRODUCTION In Nigeria, there is a dearth of pediatric data on the risk factors associated with tuberculosis (TB), before and after antiretroviral therapy (ART). METHODOLOGY A retrospective observational cohort study, between October 2010 and December 2013, at the Federal Medical Centre, Makurdi, Nigeria. TB was noted among children less than 15 years of age at ART enrolment (prevalent TB-Pr...

The epidemiology and clinical significance of fluconazole resistance were assessed in a cohort of advanced human immunodeficiency virus (HIV)-infected patients with recurrent oropharyngeal candidiasis. Fifty patients were prospectively evaluated using a novel method of detecting fluconazole resistance with chromogenic media containing fluconazole; results were confirmed with macrobroth testing....