OBJECTIVE This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. METHODS The rats were randomly divided into twelve groups: a normal diet group (NF), a high-fat diet group (HF), Orlistat group, GLC high-, middle-, and low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) h...

The anti-obesity potential of various plant extracts and their associated bioactive compounds is well known. Molecular docking studies FTO with flavonoids, using Orlistat (an drug) as a control, were performed to identify the effects Rhamnus’ flavonoids (Obesity obesity protein). Prior molecular simulation, Rhamnus flavanoids analysed AutoDockTools (version 1.5.6). Docking simulations interacti...

In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of alpha-glucosidase activity by C. asiatica extract, rutin, and acarbose was not...

Objective. To assess the efficacy and tolerability of the association sibutramine (10-20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial. Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months. Results. After 3 months, the mean weight loss wa...

The current recommendations for the treatment of obese people include increased physical activity and reduced calories intake. When the behavioral approach is not sufficient, a pharmacologic treatment is recommended. In past years, numerous drugs have been approved for the treatment of obesity; however, most of them have been withdrawn from the market because of their adverse effects. In fact, ...

Carcinoembriogenic antigen (CEA) is a serum marker commonly used as a clinical tool in the follow-up of patients with several types of tumor, particularly colorectal carcinoma. An elevation in CEA levels can precede clinical evidence of recurrence, but these levels can also increase in patients with nonmalignant pathologies. Nevertheless, an elevation in CEA levels is always associated with the...

Background: Obesity is a major problem in Saudi Arabia. Pharmaceutical solutions were sought for treatment. Chemical formula might lead to health side effects. Meanwhile, the use of herbal alleged be safe.  Green tea and apple vinegar are some these products. Objective: The study aimed measure effect green on obesity liver status compared medical drugs. Materials methods: Thirty-six adult mal...