breast cancer is the most common cancer in women. several risk factors such as age, family history of breast cancer, marital status, early menarche and late menopause are related to breast cancer. obesity is also a main health problem associated with breast cancer incidence and subsequent mortality. association between obesity and expansion of breast cancer may be due to excessive sex steroid h...

the number of patients with end-stage renal disease is growing rapidly in asia. patients with end stage renal disease failure (esrd) undergoing long term hemodialysis (hd) are at risk for high oxidative stress. there is paucity of information with regard to oxidative stress during hd. therefore, the aim of the present study was to evaluate catalase enzyme activity in erythrocytes and the total ...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. du is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. recent studies showed that uranium induces biological changes in many different target tissues, such as the kidney...

objective(s):therapies with high levels of oxygen are commonly used in the management of critical care. however, prolonged exposure to hyperoxia can cause acute lung injury. although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (hali).   materials a...

objective(s) the purpose of this study was to investigate the role of oxidative stress in purkinje cell neurotoxicity ofethanol-treated rat. materials and methods male rat pups 4-day-old was used in this study. ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (pds) 4 to 5.  pups were killed 90 min after the second alcohol treatment on pd 5 by decapitation and the bra...

objective(s) comparison of prooxidant-antioxidant balance (pab) assay with crocin assay. materials and methods twenty eight serum samples were chosen, pab and the total antioxidant capacity were measured by pab assay and crocin, respectively, and the correlation of both assays, along with their correlation with other clinical and biochemical parameters, were determined. results a significant ne...

objective(s): in the current study, the effects of selected folk medicinal herbs were evaluated in d-galactose-induced aging in male mice.   materials and methods: male balb/c mice were randomly divided into 12 groups composing sham, control, and treated groups. aging was induced by administration of d-galactose (500 mg/kg/day for 6 weeks). a positive control group was assigned that received vi...

objective(s): in the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (egcg) on lipopolysaccharide (lps)-induced hepatotoxicity by using hep3b human hepatoma cells. specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of lps-associated cytotoxicity. consequently, the hepatocellu...

objective(s): gentamicin is used for the treatment of gram-negative bacterial infections. however, gentamicin administration is limited because of nephrotoxicity. the aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. materials and methods: thirty two male wistar rats received gentamicin (100 mg/kg, ip), with or without cr...