In order to translate the findings from basic cellular research into clinical applications, cell-based models need to recapitulate both the 3D organization and multicellular complexity of an organ but at the same time accommodate systematic experimental intervention. Here we describe a hierarchy of tractable 3D models that range in complexity from organotypic 3D cultures (both monotypic and mul...

Preservation of function is a crucial aspect for the evaluation of therapies applied in the field of head and neck cancer. However, preservation of anatomic structures cannot automatically be equated with preservation of function. Functional outcome becomes increasingly important particularly for the evaluation of alternative treatment options with equivalent oncological outcomes.AS A RESULT, P...

brain death is associated with increased inflammatory cytokines levels and poor graft quality to transplant. we aimed to evaluate the impact of ascorbic acid (aa) on the inflammatory status of brain-dead donors (bdds). forty bdds were randomly divided into two groups. donor treatment (n=20) consisted of 100 mg/kg aa infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6...