Few cancers are diagnosed based on RNA expression signatures. Oral squamous cell carcinoma (OSCC) is no exception; it is currently diagnosed by scalpel biopsy followed by histopathology. This study sought to identify oral tumor epithelial microRNA (miRNA) expression changes to determine if these changes could be used to diagnose the disease noninvasively. Analysis of miRNA profiles from surgica...

Background. The purpose of this study is to understand the oral mucosal immune status of cancer patients and to make clear whether antibacterial proteins such as salivary secretory immunoglobulin (SIgA) and lysozyme in saliva were influenced by patients' health status and certain medical treatment therapy. Materials and Methods. This study included 221 patients with malignant tumor receiving an...

metastatic tumors account for 1% of all oral malignancies. metastasis to jaw bones is common, particularly in the mandible, rare in the oral soft tissues, and account for only 0.1% of oral malignancies. the majority of metastatic cases (70%) reported in the literature have primary tumors located in the lung, breast, kidney, and colon. metastasis is a biological complex process that involves det...

background: oral squamous cell carcinoma (oscc) is one of the most common malignant tumors. its incidence is rated as one among the highest in the world and the use of tobacco in various forms is increasingly associated with the cause of oscc. in oral cancer the study of tumor markers have been limited and several tumor makers with clinical promise needs further evaluation. methods: present stu...

background and objective: oral cancer accounts for less than 3% of all cancers. despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. several studies have been performed to assess factors influencing lymph node metastasis and prognosis. the aim of this study was to evaluate some clinical and pathological factors influencing lymph nod...

Neoplasia literally means the process of “new growth,” and a new growth is called neoplasm. The term tumor was originally applied to swelling caused by inflammation. Neoplasms also may induce swellings, but long precedent, non-euplastic usage has passed into limbo; thus, now equated with Oncology (Greek oncos = tumor) study tumors or neoplasm’s. Cancer common for all malignant tumors. present d...

Oral chemotherapy has many advantages over parenteral chemotherapeutics administration. To use the advantages of the oral chemotherapy and maximize anti-tumor effects of the chemotherapeutic agent, we designed HM30181A (a P-glycoprotein inhibitor) and a paclitaxel oral co-administration chemotherapeutic method. HM30181A is used to aid paclitaxel absorption from gut lumen into blood and to inhib...

Natural Killer (NK) cells target oral, pancreatic, lung, breast, glioblastoma and melanoma stem-like/poorly differentiated tumors. Differentiation of the abovementioned tumors with supernatants from split-anergized NK cells decreases their susceptibility to NK cells, but increases their sensitivity to cisplatin (CDDP)-mediated cell death. Breast and melanoma tumor cells with CD44 knockdown disp...

BACKGROUND/AIM Numerous studies were aimed to detect and characterize various tumor markers in patients with oral planocellular carcinoma in order to reduce moratlity and mobidity rates of these patients, as well as to establish the correlation between the expression of specific tumor marker and prognostic outcome. The aim of this study was to determine patohistological characteristics of tumor...

Oral squamous papilloma is a benign epithelial tumor that constitutes around 2.5% of all oral verruco-papillary lesions and caused by the Human Papilloma Virus (HPV). HPV subtypes 6 11, which are considered to be low carcinogenic potential usually associated with papilloma. Though there no site predilection as such, most common intraoral sites reported tongue, lips, buccal mucosa, gingiva, pala...