Oral administration of autoantigens is a safe and convenient way to induce peripheral T-cell tolerance in autoimmune diseases like multiple sclerosis (MS). To increase the efficacy of oral tolerance induction and obviate the need for large-scale purification of human myelin proteins, we use genetically modified lactobacilli expressing myelin antigens. A panel of recombinant lactobacilli was con...

BACKGROUND Postpartum follow up of women who have been found to have gestational diabetes during pregnancy is essential because of the strong association of gestational diabetes with subsequent type 2 diabetes. Postal reminders have been shown to increase significantly attendance for oral glucose tolerance testing postpartum. It is possible that a short message service (text) reminder system ma...

Of 20 carefully studied patients with angina pectoris given oral visammin, 4 had a significant reduction in number of pains. Eleven stated that their pains were less severe and less easily precipitated while taking visammin. There was questionable improvement in the exercise tolerance test in 2 of 9 patients after oral visammin therapy. The daily oral dose ranged from 40 mg. to 240 mg. Undesira...

Anaphylaxis induced by exercise after the intake of certain foods is referred to as food-dependent exercise-induced anaphylaxis (FDEIA). Only the preventive medication such as oral sodium cromoglycate and oral combined cetirizine-montelukast was tried in FDEIA. Specific oral tolerance induction (SOTI) using IFN-gamma was tried in 2 cases of FDEIA for wheat. Merely, exercise accompanied every tr...

Of 20 carefully studied patients with angina pectoris given oral visammin, 4 had a significant reduction in number of pains. Eleven stated that their pains were less severe and less easily precipitated while taking visammin. There was questionable improvement in the exercise tolerance test in 2 of 9 patients after oral visammin therapy. The daily oral dose ranged from 40 mg. to 240 mg. Undesira...

In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitt...

Oral glucose tolerance after either partial gastrectomy or vagotomy and pyloroplasty for duodenal ulcer was markedly affected by posture. Peak blood glucoses and the degree of reactive hypoglycaemia were greater in the erect than in the supine position. This is probably due to positional changes in gastric emptying, and our findings support the view that after gastric surgery alteration in gast...

Oral glucose tolerance test with 50g glucose was carried out with and without simultaneous oral administration of 3g calcium lactate. Blood sugar and serum immunoreactive insulin (IRI) were measured before and 30, 60, 90 and 120min after glucose load in 11 diabetics and 11 non-diabetics. Similar oral glucose tolerance test was performed with and without intravenous administration of 10ml 8.5% c...

A fascinating feature of the intestinal mucosal immune system is its ability to guard against invasion by pathogens while avoiding a response to the many potential Ags present in food. The phenomenon of systemic tolerance after oral administration of protein Ags is well documented, but the cellular and molecular basis for the observed nonresponsiveness is not fully understood. To gain insight i...

Animal models are needed to assess novel proteins produced through biotechnology for potential dietary allergenicity. Currently proposed rodent models evaluate sensitizing potential of food extracts or proteins following parenteral administration or oral administration with adjuvant. However, food allergy requires not only the potential to induce immunoglobulin (Ig) E but also the capacity to a...