Oral submucous fibrosis is a chronic debilitating disease of oral mucosa and is characterized by generalized fibrosis of the oral soft tissues which tends to present itself clinically as palpable vertical fibrous bands. Traditionally, stains such as vanGeison and various forms of trichrome have been used to detect collagen fibres in tissues. Thick and thin collagen fibres play a vital role in m...

A case of oral submucous fibrosis in a 12-year-old girl discusses its etiopathogenesis, clinical features, and histopathologic findings of the condition and highlights strong association of areca nut chewing as the potential factor in the etiology of this condition. Cessation of the areca nut chewing habit and submucosal administration of aqueous extract of healthy human placental extract (Plac...

OBJECTIVE To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF). MATERIALS AND METHODS Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied. RESULTS Cells cultured from OSF showed a statistically significant incr...

Amongst the list of pre-malignant conditions, Oral Submucous Fibrosis (OSMF) forms one of the most debilitating diseases of the oral cavity. It is predominantly seen among populations using betel quid, indicating areca nut as the most conspicuous agent in the etiological agents. A clear dosedependent relationship In relation to both the duration and frequency of chewing areca nut was revealed, ...

BACKGROUND Oral cancers can be preceded by clinically evident oral potentially malignant disorders (OPMDs). The current study evaluated the rate and the time of malignant transformation in the various OPMDs in a cohort of patients from southern Taiwan. Parameters possibly indicative for malignant transformation of OPMDs, such as epidemiological and etiological factors, and clinical and histopat...

Increased expression of inducible nitric oxide synthase (iNOS) has been found at the protein level in human oral epithelial dysplasias, but, a corresponding expression at the mRNA level has not been demonstrated. The purpose here was to assess the expression of iNOS mRNA and its correlation with the expression of the enzyme protein in human buccal premalignant epithelial lesions. Activities for...

Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and the...

BACKGROUND Oral submucous fibrosis (OSMF) is a chronic debilitating and potentially malignant condition of the oral cavity. It is resistant and progressive affecting the entire oral cavity that sometimes causes a gradual reduction in mouth opening that may even extend up to the pharynx. Although the medical treatment is not completely systematized, optimal doses of its treatment with local inje...