New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared characterized. They used as excipients to increase the solubility of two model oral drugs BCS class II, ibuprofen piroxicam. With only 0.2 mol% (≈100 mM) [N4 1 2OH]2[C4H4O4], increases over 40-fold 2-fold for ibuprofen, when compared with parent drug water phosphate buffer solution (PBS) 0.01M pH=7.4...

OBJECTIVE The objective of this study was to develop a mechanism-based pharmacodynamic model that characterizes the antiplatelet effects of aspirin (acetylsalicylic acid) and ibuprofen alone and in combination. METHODS Ten healthy volunteers were enrolled in a single-blinded, randomized, three-way crossover study. Treatments consisted of single doses of oral aspirin (325 mg) and ibuprofen (40...

Oleocanthal, a major phenolic compound in extra-virgin olive oil with antiinflammatory properties, elicits an unusual oral pungency sensed almost exclusively in the throat. This contrasts with most other common oral irritants, such as cinnamaldehyde, capsaicin, and alcohol, which irritate mucus membranes throughout the oral cavity. Here, we show that this rare irritation pattern is a consequenc...

PURPOSE We investigated if oral ingestion of ibuprofen influenced leucocyte recruitment and infiltration following an acute bout of traditional resistance exercise Methods: Sixteen male subjects were divided into two groups that received the maximum over-the-counter dose of ibuprofen (1200mg d(-1)) or a similarly administered placebo following lower body resistance exercise. Muscle biopsies wer...

Tenoxicam is an effective analgesic and anti-inflammatory agent for symptomatic treatment of various conditions. The purpose of this study was to evaluate clinically the effectiveness of prophylactic tenoxicam and prophylactic ibuprofen in reducing post-endodontic pain compared with placebo. A total of 48 patients consented to a double-blind, single dose, prophylactic oral administration of 20 ...

flammation drugs (NSAIDs) and it is clinically the first choice among its own class, 2-arylpropionic acids, due to its low incidence of unwanted effects. It contains a chiral center adjacent to the carboxyl group and thus existed as ( ) R and ( ) S enantiomers. Ibuprofen was originally marketed as racemate and later in 1994 dexibuprofen was brought into the market in Austria and Switzerland bas...

Ibuprofen is a popular over-the-counter, non-steroidal anti-inflammatory medication, frequently used for the relief of fever, headaches, menstrual and other minor pains as well as a major active ingredient in numerous cold preparations. We analyzed sales volume and data obtained from the monitoring of spontaneous reports on the adverse effects of IBUM soft capsules, IBUM Forte soft capsules, an...

The aim of this study was to compare the dissolution properties ibuprofen solid oral dosage forms commercially available in Bosnia and Herzegovina estimate influence medium composition on drug release. Eight products (A-H) were subjected vitro test using experimental conditions described USP42-NF37. Dissolution one selected product examined presence alcohol (22.2% v/v) fruit juice v/v). Product...