BACKGROUND The Canadian and American Diabetes Associations recommend the use of an oral glucose tolerance test to screen for abnormal glucose tolerance among women with polycystic ovary syndrome when their fasting plasma glucose level is 5.7 mmol/L or more (Canadian guideline) and 5.6 mmol/L or more (American). Our objective was to determine the predictive value of 5.6 mmol/L as a fasting plasm...

BACKGROUND Glucose intolerance is an untoward side effect of some immunosuppressive and anti-hypertensive drugs. The primary aim of the present prospective observational study was to test the hypothesis that tapering off prednisolone and cyclosporin (CsA) the first year after transplantation may have beneficial effects on glucose tolerance in renal transplant recipients. METHODS Ninety-one no...

The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal method (i.e., models that allow the estimation of insulin sensitivity, β-cell responsivity, and hepatic insulin extraction from a mixed-meal or an oral glucose tolerance test). Both of these oral t...

Hyperglycemia and hyperinsulinemia have been implicated in the pathogenesis of osteochondrosis (Glade et al., 1984; Ralston, 1995). More specifically, foals that experience an exaggerated and sustained increase in circulating glucose or insulin in response to a carbohydrate (grain) meal may be predisposed to development of osteochondrosis. In vitro studies with fetal and foal chondrocytes sugge...

BACKGROUND In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective of this short report was to evaluate within-patient variability of oral glucose tolerance. METHODS In total, 4,643 standardized oral glucose tolerance tests of 1,128 cystic fibrosis patients (median age at first test: 15.5 [11.5...

objective: the aim of this study was to assess the accuracy of ovarian reserve tests, mainly basal and clomiphene stimulated follicle stimulating hormone (fsh) concentrations. materials and methods : a prospective cohort study was conductedon 120 infertile patients referring to mirza koochak khan hospital for ivffrom 2004 to 2006. all the patients underwent clomiphene citrate challenge test (cc...

Insulin and non-esterified fatty acids (NEFA) are important regulators of triglyceride metabolism. The relations between these compounds and the effect of a common 3 amino acid deletion in the apolipoprotein B (ApoB) signal peptide (SP) following an oral glucose challenge have been investigated. The frequency of the shorter SP-24 allele was 32% (95% C.I. 29.5-36.5) in 725 subjects undergoing an...