On the basis of results obtained from an oral glucose tolerance test, (OGTT), twenty patients with gonadal dysgenesis were classified as normal (N = 8) and diabetic (N = 12). The two groups of patients were further tested by a rapid intravenous glucose injection, a tolbutamide test, an insulin sensitivity test and an oral amino acid load. Fasting levels of plasma growth hormone (GH) were normal...

BACKGROUND Postpartum follow up of women who have been found to have gestational diabetes during pregnancy is essential because of the strong association of gestational diabetes with subsequent type 2 diabetes. Postal reminders have been shown to increase significantly attendance for oral glucose tolerance testing postpartum. It is possible that a short message service (text) reminder system ma...

Sir, Sandhu et al.1 showed convincingly that oral rehydration with a glucose-polymer solution (12.5 g/100 ml, giving 730 mmol/l glucose) and 90 mmol/l sodium predisposes to hypernatraemia. In so doing they reproduced the circumstances that contributed to the epidemic of hyper-natraemia in the 1950s.2 At that time commercial oral rehydration solutions were changed to high concentrations of gluco...

An obese animal model having mild glucose intolerance was developed by intravenous administration of sub-optimal dose of alloxan to British Angora rabbits. Mild hypoglycaemic activity of crude extract prepared from leaves of a Nepalese herb Biophytum sensitivum, which was missed by the conventional diabetic animal models, was demonstrable in these animals. Initial fasting hyperglycaemia observe...

OBJECTIVE Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) unde...

  Background : Magnesium is the second most abundant intracellular cation. It plays an important role in insulin homeostasis and glucose metabolism through multiple enzymatic reactions. With increasing data on magnesium deficiency in diabetic patients and epidemiological studies demonstrating magnesium deficiency as a risk factor for diabetes, it is logical to search for its possible beneficial...