نتایج جستجو برای: oral dosing
تعداد نتایج: 277969 فیلتر نتایج به سال:
This article has not been copyedited and formatted. The final version may differ from this version. Abstract: The objective of this study was to determine the bioavailability and disposition of elacridar (GF120918) in plasma and brain after various routes of administration in the mouse. Elacridar is a potent inhibitor of P-gp and BCRP and has been used to examine the influence of these efflux t...
OBJECTIVE The recommended dosing frequency of oral penicillin for the treatment of acute streptococcal tonsillopharyngitis has long been 3 to 4 times daily. In 1994, treatment guidelines included twice-daily (BID) dosing for the first time, a recommendation that could significantly increase the ease of compliance. This meta-analysis was performed to determine whether overall cure rates differed...
organic nitrates are commonly used in angina pectoris and ischemic cardiomyopathy. in order to optimize their effectiveness and patient convenience, several aspects must be observed. adequate doses, suitable dosage forms and asymmetric pattern of usage to prevent the nitrate tolerance are some factors that a physician must be familiar with. the objective of the present study was to define the p...
Organic nitrates are commonly used in angina pectoris and ischemic cardiomyopathy. In order to optimize their effectiveness and patient convenience, several aspects must be observed. Adequate doses, suitable dosage forms and asymmetric pattern of usage to prevent the nitrate tolerance are some factors that a physician must be familiar with. The objective of the present study was to define the p...
OBJECTIVES Inaccurate antibiotic dosing can lead to treatment failure, fuel antimicrobial resistance and increase side effects. The British National Formulary for Children (BNFC) guidance recommends oral antibiotic dosing according to age bands as a proxy for weight. Recommended doses of amoxicillin for children were increased in 2014 'after widespread concerns of under dosing'. However, the im...
Dosing convenience is a key element in the effective management of any chronic disease, and is particularly important in the long-term management of osteoporosis. Less frequent dosing with any medication may enhance compliance, thereby maximizing the effectiveness of therapy. Animal data support the rationale that once-weekly dosing with alendronate 70 mg (7 times the daily oral treatment dose)...
introduction: the purpose of this study was to compare the efficacy and side effects of two different misoprostol regimens for second-trimester pregnancy termination. methods: 60 consenting women who were at 14 to 28 weeks of gestation with indications for pregnancy termination were randomly assigned to two equal groups to receive either vaginal or oral misoprostol. the dosing regimen was 400µg...
The pharmacokinetic properties of fluconazole are similar following administration by the intravenous or oral routes. In normal volunteers, the bioavailability of orally administered fluconazole is over 90% compared with intravenous administration. Bioequivalence was established between the 100 mg tablet and both suspension strengths when administered as a single 200 mg dose. Peak plasma concen...
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