To assess the effect of oral contraceptives on antinuclear antibodies (ANAs), rheumatoid factor (RF), and C-reactive protein (CRP), 3 groups of women were studied: 1) 174 women (ages 16-47) from the time of their initial uses of oral contraceptives, 2) 119 women (ages 17-39) selected from the community at random, and 3) 210 women (ages 17-47) who had been taking oral contraceptives prior to an...

BACKGROUND There is an increased risk of venous thromboembolism among women taking oral contraceptives. However, whether there is an additional risk among women with polycystic ovary syndrome (PCOS) is unknown. METHODS We developed a population-based cohort from the IMS LifeLink Health Plan Claims Database, which includes managed care organizations in the United States. Women aged 18-46 years...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among females of reproductive age. In adolescents, PCOS often manifests with irregular menses, hirsutism, and acne. Despite general agreement that the metabolic derangements of PCOS arise during puberty, the condition is diagnosed more often in adults than in adolescents. Treatment is focused on weight loss, menstrual cycle regu...

background & aim: sexual health is an essential element of quality of life, affecting both physical and psychological domains. hormones used in contraceptive methods have contradictory effects on sexual function. in this study, we aimed to compare sexual function in women using combined oral contraceptives (coc) and depot medroxyprogesterone acetate (dmpa), referred to healthcare centers affili...

affection in the adolescent population (French, 2005; Harel, 2002) and different studies have reported prevalence rates ranging from 25% up to 90% of females in the samples studied (Larroy, Crespo, & Meseguer, 2001; Polat et al., 2009). This affection is very common during the teenage years after the menarche and less often in women after the age of 20-25 years (Freeman, Rickels, & Sondheimer, ...

The higher risk of venous thromboembolism with 3rd and 4th- generations combined oral contraceptives compared to 2nd generation triggered a media crisis in France. Exposure to 3rd or 4th-generation combined oral contraceptives led to an annual excess of around 100 premature deaths in Europe. In the absence of any demonstrated additional benefit of these combined oral contraceptives, measures we...

Germline mutations in BRCA1 or BRCA2 genes redispose to hereditary breast and ovarian cancers. he estimated lifetime risk of breast cancer in BRCA1 utation carriers ranges from 50% to 80%, while the stimated lifetime risk of ovarian cancer ranges from 0% to 65%. Although breast cancer risk is similar in omen who inherit BRCA2 mutations, the lifetime risk f ovarian cancer is approximately 20% [1...

BACKGROUND The effects of oral contraceptives (OCs) on mental health are not clear, and no study has been focused on the effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on mental health. The aim of this study was to analyse the association between the use of OCs and the LNG-IUS and psychological well-being and psychopathology. METHODS The associations between the current...

Cyclin D1, an important cell cycle regulator, is overexpressed in several human cancers including breast. Both estrogens and progestins activate the transcription of the gene; antiestrogens have been shown to reduce cyclin D1 protein levels. Cyclin D1 protein overexpression has been strongly associated with well-differentiated, estrogen receptor-positive tumors. Little is known, however, as to ...

Differentially-expressed genes (DEGs) correlated to oral contraceptives (OCs) were identified by comparing the transcriptomes of cervical cancer patients who have taken OCs and those who have not. Their biological functions and relevance to clinical manifestations were investigated further in order to gain an understanding of the pathogenesis of cervical cancer and provide potential therapeutic...