Introduction: T1 contrast is typically acquired using multi-slice two-dimensional spin-echo (2D SE), inversion recovery fast spin echo (T1 fluid-attenuated inversion recovery : T1FLAIR) or 3D T1-weighted spoiled gradient-echo (3D T1TFE) imaging [1]. However, these conventional methods have problems when used for contrast enhancement studies. 2D-SE requires long scan time for 3-plane diagnosis, ...

PURPOSE Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H96 approach. METHODS The nanosuspension of aprepitant was prepared by HPH and H96 approach. The ...

The hot water extract of dry kinkéliba leaves (DKL) is a traditionally widely delighted and consumed beverage in West Africa, especially during the fasting periods. It is believed to possess various health benefit effects such as diuretic, purgative, digestive, anti-viral and anti-malarial properties. However, the preparation of this beverage has not been optimized so far, which may underestima...

background: nickel is an important constituents widely used in different industrial processes for production of various syn¬thetic materials. for evaluation of workers’ exposure to trace toxic metal of ni (ii), environmental and biological monitor¬ing are essential processes, in which, preparation of samples is one of the most time-consuming and error-prone as¬pects prior to analysis. methods: ...

This paper proposes a swarm optimized fuzzy logic based power system stabilizer (SFLPSS). The fuzzy logic stabilizer membership functions parameters, inputs and outputs gains and fuzzy rules are tuned and optimized using particle swarm optimization (PSO) technique. Optimization parameters were subject to realistic constraint. The optimization is done using a seventh order nonlinear model of a s...

The importance of bioconjugates within the field of chemistry drives the need for novel methodologies for their preparation. Well-defined and stable bioconjugates are easily accessible via the utilization of unnatural amino acids (UAAs). As such, we have synthesized and incorporated two new UAAs into green fluorescent protein, and optimized a novel Cadiot-Chodkiewicz bioconjugation, effectively...

We describe a "gel-assisted" proteomic sample preparation method for MS analysis. Solubilized protein extracts or intact cells are copolymerized with acrylamide, facilitating denaturation, reduction, quantitative cysteine alkylation, and matrix formation. Gel-aided sample preparation has been optimized to be highly flexible, scalable, and to allow reproducible sample generation from 50 cells to...

urinary 1-hydroxypuren (1-ohp) is commonly used as a major metabolite and biological indicator of the overall exposure to polycyclic aromatic hydrocarbons (pahs). for evaluation of human exposure to such compounds, biological monitoring is an essential process, in which, preparation of samples is one of the most time-consuming and error-prone aspects prior to chromatographic techniques. in this...

This article is focused on the determination of lidocaine hydrochloride as a local anaesthetic drug. A potentiometric method based on modified screen-printed and modified carbon paste ion-selective electrodes was described for the determination of lidocaine hydrochloride in different pharmaceutical preparations. It was based on potentiometric titration of lidocaine hydrochloride using modified ...