BACKGROUND In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. METHODS Eleven consecutive patients presenting to...

Swelling of the optic disc may result from inflammation, infiltration, nerve compression or ischaemia, as well increased intracranial pressure. It can be imitated by local structural features leading to pseudopapilloedema. Disease entities swelling take different courses in paediatric population compared adult population. Investigations used confirm diagnosis include optical coherence tomograph...

during the past few years, researchers and practitioners have developed novel techniques, using ansa cervicalis to innervate muscles of the larynx paralyzed due to surgical procedures carried out in the chest and neck areas. during routine dissection of a middle-age male cadaver, an unusual course of the superior root of the ansa cervicalis was observed. in this case, the superior root of the a...

Purpose Glaucoma damages the retinal nerve fiber layer (RNFL). This study used precise multimodal image registration to investigate the changes of the RNFL reflectance spectrum and birefringence in nerve fiber bundles with different degrees of axonal damage. Methods The reflectance spectrum of individual nerve fiber bundles in normal rats and rats with experimental glaucoma was measured from ...

Primary non-Hodgkin lymphoma (PNHL) of the sphenoid sinus is a rare neoplasm that poses a diagnostic challenge to clinicians. The proximity of the optical nerve and canal to the sphenoid sinus is accountable for the high incidence of visual disturbance in PNHL of the sphenoid sinus. In particular, patients whose radiologic diagnosis reveals bone destruction in the lateral wall involved with opt...

OBJECTIVE To evaluate macular changes in eyes with papilledema from increased intracranial pressure using optical coherence tomography (OCT). METHODS Fifty-five patients with papilledema seen during 1998 and 1999 were studied with OCT of the optic nerve and retinal nerve fiber layer. Nineteen of these also had OCT of the macula during periods of acute, subacute, or recurrent papilledema and w...

We cross-sectionally examined the relationship between age, optic disc area, refraction, and gender and optic disc topography and retinal nerve fiber layer (RNFL) measurements, using optical imaging techniques. One eye from each of 155 Caucasian subjects (age range 23.0-80.8 y) without ocular pathology was included. Measurements were obtained by using the Heidelberg Retina Tomography (HRT), the...

Bilateral optic neuropathy in Dar es Salaam is now considered endemic and is estimated to affect 0.3-2.4% of young adults. The condition is characterized by a subacute bilateral loss of central vision of unknown aetiology. Findings of spectral domain optical coherence tomography have not previously been reported for these patients. All patients diagnosed with endemic optic neuropathy over a 2-y...

PURPOSE To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in normal eyes and eyes with glaucoma using spectral domain optical coherence tomography (SDOCT). METHODS One eye of 79 normal and 72 glaucoma patients was analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressur...

Recent advances in optical imaging techniques allow us to acquire the structure of living nerve cells and their changes. While the commonly used dye-stained extrinsic optical signal mimics the intracellular voltage or the ion currents of the membrane directly, the fast intrinsic optical signal measures longer term physiological changes such as cell structure and sub-cellular level properties af...