Congenital megalourethra is a rare mesenchymal anomaly of the male urethra, characterised by severe dilatation of the penile urethra due to congenital absence of the corpus spongiosum and/or corpus cavernosum. Postnatal complications include voiding and erectile dysfunction as well as renal insufficiency and pulmonary hypoplasia. We present a unique case of congenital megalourethra diagnosed pr...

Recent discovery of hair follicle keratin 75 (KRT75) in enamel raises questions about the function of this protein in enamel and the mechanisms of its secretion. It is also not clear how this protein with a very specific and narrow expression pattern, limited to the inner root sheath of the hair follicle, became associated with enamel. We propose a hypothesis that KRT75 was co-opted by amelobla...

The article analyzes the evolution of parliamentary form government, which highlights growing importance government and progressive marginalization Parliament. Constituent Assembly opted for a government. A decisive argument put forward during discussion in favour system was concern over an

The present review assesses the phylogenetic history of information molecules (bioregulators pheromones, hormones, neuroactive compounds), receptors, transducers, second messengers) in uni- and multicellular organisms. Transitional stages between contemporary endocrine secretions including hormones and neuroactive materials, and primogenial exocrine compounds (pheromones) are proposed. Severalh...

The working party on the GMC in the 1990s opted for a compromise and recommended that "a member of staff should be trained to handle press and public relations matters on behalf of the council." The council has, however, decided to appoint a full time press and public relations officer and the post has been advertised. But what may be needed more than a person to do the job is a change of attit...

The study assessed the opinions of the Pakistani library experts in terms of: organization for digitization work (execution of digitization work & staffing patterns); funding patterns; and access patterns for digitization projects. The study opted qualitative research design and indepth interviews were conducted to collect the data from purposely selected library experts from different parts of...

The patient is a 59-year-old formerly smoking male with a history of T2N0M0, stage I colon cancer. He underwent a left hemicolectomy five years prior to presentation and was referred for an enlarging 7 mm pulmonary nodule noted on surveillance imaging. His past medical history was significant for coronary artery disease and hypertension. Given the deep location of the pulmonary nodule and the p...

We made the diagnosis prenatally from cytogenetic analysis of amniocytes cultured following amniocentesis performed at 20 weeks’ gestation on a woman in whom ultrasound examination of the female fetus showed severe growth retardation, lung and kidney hypoplasia, and a congenital heart defect. Analysis revealed a de novo trisomy of the terminal short arm of chromosome 4 (4p16.1-pter). The parent...

Background Research on potential perinatal risk factors for asthma, has recently attracted considerable attention. Asthma could be associated with In vitro fertilization (IVF) via epigenetic modification of DNA by IVF drugs/hormones or via a genetic link of asthma with parental subfertility. Nevertheless, evidence of an asthma/IVF correlation is scarce and inconclusive. We therefore opted to ex...