Outer membrane proteins (OMPs) play a central role in the integrity of the outer membrane of Gram-negative bacteria. Unfolded OMPs (uOMPs) transit across the periplasm, and subsequent folding and assembly are crucial for biogenesis. Chaperones and the essential β-barrel assembly machinery (BAM) complex facilitate these processes. In vitro studies suggest that some chaperones sequester uOMPs in ...

The outer membrane (OM) of gram-negative bacteria such as Escherichia coli contains lipoproteins and integral β-barrel proteins (outer-membrane proteins, OMPs) assembled into an asymmetrical lipid bilayer. Insertion of β-barrel proteins into the OM is mediated by a protein complex that contains the OMP BamA and four associated lipoproteins (BamBCDE). The mechanism by which the Bam complex catal...

While heterotrophic microorganisms constitute the major fraction of activated sludge biomass, role heterotrophs in biotransformation organic micropollutants (OMPs) has not been fully elucidated. Yet, such knowledge is essential, particularly when conceiving novel wastewater treatment plants based on a two-stage process including an A-stage under conditions and B-stage anammox activity. Biotrans...

There is a growing interest in Biological investigation to determine the location of proteins, to identify new potentially accessible drug targets. Signal peptide directs the transport of the protein to its location. Bacterial OMPs are essential for their survival in the host organism. SIGLOCPRED a signal peptide predictor for the bacterial proteins as well as OMP prediction has been developed....

Neisseria meningitidis serogroup B is a major cause of bacterial meningitis in younger populations. The available vaccines are based on outer membrane vesicles obtained from wild-type strains. In children less than 2 years old they confer protection only against strains expressing homologous PorA, a major, variable outer membrane protein (OMP). We genetically modified a strain in order to elimi...

Three imipenem-resistant mutants were obtained from a clinical isolate (C152) of Shigella dysenteriae by selection with increasing concentrations of imipenem. Resistance to imipenem was associated with resistance to several other beta-lactam antibiotics. The penicillin-binding protein (PBP) patterns of the resistant and the wild-type strains were comparable. The permeability of the outer membra...

Introduction The E.coli outer membrane (OM) is densely packed with outer membrane proteins (OMPs) that carry out a diverse range of functions that include (non)specific transport of small and large ligands, proteolytic and synthetic reactions and cellular recognition and adhesion. However, despite their importance, understanding the biogenesis of OMPs and their folding and insertion into membra...

The Ozone Mapping and Profiler Suite (OMPS) nadir sensor and algorithms for the United States National Polarorbiting Operational Environmental Satellite System (NPOESS) comprise a system to map ozone total column globally in 24 hours and to measure the altitude distribution of ozone in the upper stratosphere (30-50 km). The sensor consists of a wide field (110 degree) telescope and two spectrom...

Assembly of dsDNA bacteriophage is a precisely programmed process. Potential roles of host cell components in phage assembly haven't been well understood. It was previously reported that two unidentified proteins were present in bacteriophage Sf6 virion (Casjens et al, 2004, J.Mol.Biol. 339, 379-394, Fig. 2A). Using tandem mass spectrometry, we have identified the two proteins as outer membrane...

This study examines the possibility to apply the theory of multidimensional accounting (momentum accounting) in a Brazilian Navy’s Services Provider Military Organization (Organização Militar Prestadora de Serviços OMPS). In general, the core of the said theory is the fact that Accounting does not recognize the inertia of transactions occurring in an entity, and that occur repeatedly in some ca...