BACKGROUND The growth in expenditure on orphan medicinal products (OMP) across Europe has been identified as a concern. Estimates of future expenditure in Europe have suggested that OMPs could account for a significant proportion of total pharmaceutical expenditure in some countries, but few of these forecasts have been well validated. This analysis aims to establish a robust forecast of the fu...

Neisseria gonorrhoeae isolated from patients with disseminated infection (DGI) often resist complement (C')-dependent killing by normal human serum (NHS) and less commonly by convalescent DGI serum. 7 of 10 NHS specimens completely inhibited killing of serum-resistant (ser(r)) gonococci by convalescent or immune DGI serum. Immunoglobulin G (IgG) purified from NHS was shown to be the blocking ag...

Haemorrhagic septicemia (HS) caused by Pasteurella multocida (serotype B: 2) is an important disease of cattle and buffaloes in Asian sub-continent. Presently available vaccines for HS have their own limitations. Efforts have been made to develop better vaccine targeting outer membrane proteins and few of them have shown potential . Omp 87 protein has shown a protective potential against fowl c...

Complex U consists of orotate phosphoribosyltransferase (EC 2.4.2.10) and orotidineG’-phosphate decarboxylase (EC 4.1.1.23), the last two enzymes of the de nova pathway for UMP biosynthesis. Earlier studies had shown that orotate and magnesium 5-phosphoribosyl-1-pyrophosphate, substrates for the transferase, and orotidine 5’-monophosphate (OMP), the product of the transferase and also the subst...

This study investigated sorption and biodegradation behaviour of 14 organic micropollutants (OMP) in soil columns representative of the first metre (oxic conditions) of the river bank filtration (RBF) process. Breakthrough curves were modelled to differentiate between OMP sorption and biodegradation. The main objective of this study was to investigate if the OMP biodegradation rate could be rel...

Sera from pigs infected with Haemophilus (Actinobacillus) pleuropneumoniae were tested for antibodies to outer membrane proteins (OMPs) of the organism by immunoblotting. Convalescent sera were produced in naturally born, colostrum-fed pigs and in cesarean-derived, colostrum-deprived pigs given H. pleuropneumoniae serotype 5 intranasally twice at 5-week intervals. Sera, collected at weekly inte...

Radiographic interpretation skill is the most essential skill for a dental undergraduate to obtain the degree of Bachelor of Dental Surgery and also to be a competent private dental practitioner. Despite the various teaching techniques, radiographic interpretation is quite a challenging task. One minute preceptor (OMP) model is widely used for active teaching in busy clinical setting, and the s...

Molecular dynamics simulations have been used to derive the structures of ground (orotidine-5'-monophosphate decarboxylase x orotidine 5'-monophosphate; ODC x OMP) and intermediate (ODC x intermediate; ODC x I(-)) states in the ODC-catalyzed decarboxylation of OMP. For comparison, a molecular dynamics simulation of the conformers of OMP dissolved in water was also studied. This structural infor...

Age-related changes in cell proliferation, neuronal differentiation, and cell death in mouse olfactory neuroepithelium were investigated. Mice at the age of 10 days through 16 months were given a single injection of bromodeoxyuridine (BrdU). The olfactory mucosae were fixed at 9 timepoints ranging from 2 hours to 3 months after the injection and examined using double immunostaining for BrdU and...

Molecular genetic manipulation of mycobacteria would benefit from the isolation of mycobacterial genes that could serve both as genetic markers and as sequences used to target homologous integration of recombinant DNA into the genome. We isolated the Mycobacterium bovis BCG gene encoding orotidine-5'-monophosphate decarboxylase (OMP-DCase) by complementing an Escherichia coli mutant defective i...