dried oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to fivenative female goats. clinical signs of toxicosis in goats began to appear about 1 hr after receiving theoleander and included abdominal pain, ruminal atony and tympany, frequent urination, bradycardia,tachycardia, tachyarrhythmia, depression, weakness and convulsive movement and death at the end...

Lipid-soluble cardiac glycosides such as bufalin, oleandrin, and digitoxin have been suggested as potent agents that might be useful as anticancer agents. Past research with oleandrin, a principle cardiac glycoside in Nerium oleander L. (Apocynaceae), has been shown to induce cell death through induction of apoptosis. In PANC-1 cells, a human pancreatic cancer cell line, cell death occurs not t...

OBJECTIVE The goal for this study was to evaluate the effects of an Aloe vera-based Nerium oleander extract (NAE-8(®)), compared to an extract of A. vera gel alone (ALOE), and to an aqueous extract of N. oleander (AQ-NOE) in bioassays pertaining to dermatologic potential with respect to antioxidant protection, anti-inflammatory effects, and cytokine profiles in vitro. METHODS Cellular antioxi...

Since, landfill areas are still the most widely used solid waste disposal method across the world, leachate generated from landfills should be given importance. Leachate of landfills exerts environmental risks mostly on surface and groundwater with its high pollutant content, which may cause unbearable water quality. This leads to the obligation for decontamination and remediation program to be...

The current treatment of febrile conditions involves non-steroidal anti-inflammatory drugs (NSAIDs), which are widely prescribed because their efficacy in the management pain, fever, and inflammation. However, long-term therapeutic use is often associated with adverse effects such as gastrointestinal ulcers. Therefore, research based on substitution chemical treatments natural that equally effe...

Plant poisoning is not an uncommon problem in Sri Lanka. A hospital based prospective study showed that Jatropha curcas, Ricinus communis, Dieffenbachia, Adenia palmata, Amanita phalloides and Thevetia peruviana are common poisonous plants implicated in poisoning among children in Sri Lanka. [1]. In the past, deliberate ingestion of yellow oleander seeds (Thevetia peruviana) was a common method...