among numerous np-hard problems, the traveling salesman problem (tsp) has been one of the most explored, yet unknown one. even a minor modification changes the problem’s status, calling for a different solution. the generalized traveling salesman problem (gtsp)expands the tsp to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

The possibility that an infant’s diet may influence the later development of obesity or of atheroma gives this subject its interest and importance. The concept of the body’s depot fat as constituting an ‘organ’ is probably a useful one, but only so long as it does not lead to unwarranted simplification. For instance, samples of depot fat taken from the adipose tissue of a baby’s buttock tend to...

A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on ma...

OBJECTIVE To report a case of right posterior subcapsular cataract induced by 3-monthly depot luteinizing hormone-releasing hormone (LHRH) analogue therapy in a patient with early prostate cancer. CASE PRESENTATION A 52-year-old male with static myopia of several years' duration was given a 3-month depot LHRH analogue (goserelin 10.8 mg) as part of neoadjuvant treatment for early prostate can...

It has long been recognized that body fat distribution and regional adiposity play a major role in the control of metabolic homeostasis. However, the ability to study and compare the cell autonomous regulation and response of adipocytes from different fat depots has been hampered by the difficulty of inducing preadipocytes isolated from the visceral depot to differentiate into mature adipocytes...

PURPOSE The aim of this longitudinal study was to determine whether the depot formulation of an antipsychotic reduces violence in outpatients with schizophrenia as compared to oral administration of the same antipsychotic. METHODS Forty-six previously violent patients with schizophrenia were randomised to receive treatment with oral or depot zuclopenthixol for 1 year. Clinicians interviewed p...

This paper focuses on a modified Multi-Depot Unmanned Aerial Vehicle Routing Problem (MMDUAVRP). Comparing to classic multi-depot vehicle routing problem, our studied problem has no constraints restrict the depot where (UAV) departs and returns. work aims minimize number of UAVs total distance traveled by all UAVs. is mathematically formulated in this heuristic-assignment based hybrid large nei...

The Rental Fleet Scheduling Problem (RFSP) arises in vehicle rental operations that offer a wide variety of vehicle types to customers, and allow a rented vehicle to “migrate” to a setdown depot other than the pickup depot. When there is a shortage of vehicles of a particular type at a depot, vehicles may be relocated to that depot, or vehicles of similar types may be substituted. The RFSP invo...

PURPOSE Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients ...