نتایج جستجو برای: oh
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The most biologically active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has well known direct effects on osteoblast growth and differentiation in vitro. The precursor 25-hydroxyvitamin D3 (25(OH)D3) can affect osteoblast function via conversion to 1,25(OH)2D3, however, it is largely unknown whether 25(OH)D3 can affect primary osteoblast function on its own. Furthermore, 25(OH)D3 is not o...
Paraloid-Mg(OH)2 nanocomposites were synthesized via sonochemical method. Nanostructures were characterized by XRD and SEM. Thermal stability behavior of paraloid filled with magnesium hydroxide was investigated by thermogravimetric analysis (TGA). The influence of Mg(OH)2 nanostructures on the flame retardancy of the paraloid matrix was studied using UL-94 analysis. Our r...
سابقه و هدف: کاهش سطوح (OH)D 25 سرم در نمونه‌های مبتلا به اختلال تحمل گلوکز و دیابتی‌های نوع 2 گزارش شده است. به منظور مقایسه وضعیت ویتامین D بیماران دیابتی و افراد سالم یک بررسی پایلوت بر روی بیماران دیابتی نوع 1 (30 نفر)، دیابتی نوع 2 (30 نفر) و نمونه‌های سالم (30 نفر) در طی پائیز و زمستان 1384 انجام شد. مواد و روش ها: آنالیز سرم از نظر مقدار 25 هیدروکسی کوله کلسیفرول با استفاده از 3 روش HP...
Hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) are inhibitors and substrates for various human sulfotransferases (SULTs). Although the rat is often used in toxicological studies on PCBs, the interactions of OH-PCBs with rat SULTs are less well understood. In the present study, 15 OH-PCBs were investigated as potential substrates or inhibitors of purified recombinant rSULT1A1 an...
The effects of berberine on the in vivo N-acetylation and metabolism of 2-aminofluorene (2-AF) in bladder, blood, colon, kidney, liver, feces and urine samples and brain tissues (cerebrum, cerebellum and pineal gland) of male Sprague-Dawley rats were investigated. Major metabolites, such as 1-OH-2-AAF, 3-OH-2-AAF, 8-OH-2-AAF and 9-OH-2-AAF were found in bladder tissues, 1-OH-2-AAF, 5-OH-2-AAF a...
To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we analyzed samples of human serum and epidermis, and pig adrenals for the presence of intermediates and products of these pathways. We extracted human epidermis from 13 individuals and sera from 13 individuals and analyze...
Cytochrome P450scc (CYP11A1) can hydroxylate vitamin D(3), producing 20S-hydroxyvitamin D(3) [20(OH)D(3)] and 20S,23-dihydroxyvitamin D(3) [20,23(OH)(2)D(3)] as the major metabolites. These are biologically active, acting as partial vitamin D receptor (VDR) agonists. Minor products include 17-hydroxyvitamin D(3), 17,20-dihydroxyvitamin D(3), and 17,20,23-trihydroxyvitamin D(3). In the current s...
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