The use of disease-free survival (DFS) as a surrogate endpoint for overall may speed up clinical research in cancer trials. Validation DFS OS neoadjuvant treatment oesophageal and gastro-oesophageal junction is still uncertain. We used Individual patient data from network meta-analysis chemotherapy or chemoradiotherapy esophageal gastro-esophageal carcinoma (MANATEC-02). Eligible trials were ra...

BACKGROUND Recent studies have suggested that the Epstein-Barr virus (EBV) is associated with smooth muscle tumours (leiomyoma and leiomyosarcoma) in patients with human immunodeficiency virus and in organ transplant recipients. Leiomyoma is the most common mensenchymal tumour found in the oesophagus. AIM To report a single institution experience on oesophageal mesenchymal tumours and to dete...

BACKGROUND Dietary habits influence the risk of cancer of the oesophagus and oesophago-gastric junction, but the role of proportions of the main dietary macronutrients carbohydrates, fats and proteins is uncertain. METHODS Data was derived from a nationwide Swedish population-based case-control study conducted in 1995-1997, in which case ascertainment was rapid, and all cases were uniformly c...

BACKGROUND AND AIMS The increasing use of endoscopic resection for curative treatment of early oesophageal cancers requires accurate staging before therapy. In a prospective blinded trial, we compared staging of early oesophageal carcinoma using high resolution endoscopy (HR-E) with staging using high resolution endosonography (HR-EUS). PATIENTS AND METHODS A total of 100 patients (89 men, 11...

A 58-year-old lady presented with persistent dysphasia, more for solids than liquids, associated with vomiting and loss of appetite since 1 month. She gave a history of insertion of Mosseau-barbin (MB) tube for chronic dysphasia 15 years ago. Barium swallow demonstrated an oesophageal stent insitu along with dilatation of the lower end of the oesophagus with stagnation of contrast and “bird-bea...

Perforation of the oesophagus is an occasional tragic complication of endoscopy. It is most liable to occur when a carcinoma is present in the oesophagus. The three cases of perforation following dilatation of oesophageal strictures which we are reporting are of interest as the mechanism of rupture and surgical pathology was different in each case. The result of surgical intervention was gratif...

Squamous cell carcinoma In Western countries, oesophageal carcinomas with squamous cell differentiation typically arise after many years of tobacco and alcohol abuse. They frequently carry G:C >T:A mutations of the TP53 gene. Other causes include chronic mucosal injury through hot beverages and malnutrition, but the very high incidence rates observed in Iran and some African and Asian regions r...