Dysregulation of TGF,62, a modulator of cell growth and differentiation, can result in uncontrolled growth and tumor formation. Our comparative studies on the expression of TGF (2 mRNA and protein indicate that TGF (2 may primarily be a regulator of epithelial differentiation during tooth development (between 13 and 20 gestational wk) and tumorigenesis of odontogenic neoplasms. A paracrine mode...

Dysregulation of TGF beta 2, a modulator of cell growth and differentiation, can result in uncontrolled growth and tumor formation. Our comparative studies on the expression of TGF beta 2 mRNA and protein indicate that TGF beta 2 may primarily be a regulator of epithelial differentiation during tooth development (between 13 and 20 gestational wk) and tumorigenesis of odontogenic neoplasms. A pa...

Light and electron microscopy were used to analyze the epithelial lining of odontogenic cysts excised from edentulous regions of the jaws. Clinically, three cases were identified as keratocysts, and 21 cases as cysts other than keratocysts ("non-keratocysts"). The epithelium of the former was found to achieve keratinization over most of the surface and to never contain mucus secreting cells. Th...

Purpose: Odontogenic cysts and tumors comprise a major component of lesions the oral maxillofacial region. The pathogenesis these involves interaction between odontogenic epithelium ectomesenchyme. However, clinical behavior biological entities is unpredictable. aim this study was to evaluate role Cyclooxygenase 2 (COX-2) in prognostication lesions.Material method: : In formalin-fixed paraffin-...

An adenomatoid odontogenic tumour (AOT) is a unique and somewhat uncommon that only arises from epithelium makes up between 2 7% of all tumours cysts. The lesion categorised into three variants, the most common which follicular type, frequently presents as dentigerous cyst clinically because it surrounds an impacted tooth. Because lesion's well-known ability to take on various clinical histopat...

Paradental cysts are rare cystic lesions that develop on buccal, distal and rarely mesial side of the mandibular permanent molars in the period of their eruption. They belong to the group of inflammatory cysts and constitute less than 5% of all odontogenic cysts [1]. Most often they are associated with recurrent pericoronitis of semi-impacted wisdom teeth (61.4%) at the time of their eruption, ...

Tooth morphogenesis results from reciprocal interactions between oral epithelium and ectomesenchyme culminating in the formation of mineralized tissues, enamel, and dentin. During this process, epithelial cells differentiate into enamel-secreting ameloblasts. Ameloblastin, an enamel matrix protein, is expressed by differentiating ameloblasts. Here, we report the creation of ameloblastin-null mi...

OBJECTIVES Odontogenic keratocysts (OKCs) are developmental cysts that have been reclassified according World Health Organization (WHO), to keratocystic odontogenic tumours (KCOTs), a term that better reflects their neoplastic nature. The aim of present study is to evaluate the induction of stress of the endoplasmic reticulum and execution of the resulting unfolded protein response in keratinoc...