Disadvantages of conventional drug delivery systems (DDS), such as systemic circulation, interaction with physiochemical factors, reduced bioavailability, and insufficient concentration at bone defect site, have underlined the importance developing efficacious local systems. Octacalcium phosphate (OCP) is presumed to be precursor biologically formed apatite, owing its similarity hydroxyapatite ...

Octacalcium phosphate (OCP) has attracted the interest of researchers looking for new biomaterials due to its excellent biocompatibility and high formability. Furthermore, it was an attraction medical combination products that ions molecule doping ability OCP, which originated distinct crystal structure. Then, as antibacterial bone substitute, Ag-substituted OCP (OCP-Ag) a candidate centerpiece...

Many questions remain regarding the formation of ultrathin hydroxapatite (HAP) crystals within the confines of collagen fibrils of bones. These structures form through the interplay of the collagen matrix and non-collagenous proteins, and in vitro mineralization studies employing poly(aspartic acid) (PAsp) as a mimic of the non-collagenous proteins have generated mineralized fibrils with struct...

Amorphous Calcium Phosphate (ACP) is an essential mineral phase formed in mineralized tissues and the first commercial product as artificial hydroxyapatite. ACP is unique among all forms of calcium phosphates in that it lacks long-range, periodic atomic scale order of crystalline calcium phosphates. The X-ray diffraction pattern is broad and diffuse with a maximum at 25 degree 2 theta, and no o...

Osteoarthritis (OA) is the most common form of arthritis that occurs in humans. Despite its prevalence, the pathogenesis of OA is not fully understood. Intraarticular basic calcium phosphate (BCP) (an inclusive term for partially carbonate-substituted hydroxyapatite, octacalcium phosphate and tricalcium phosphate) crystals are implicated in OA and are associated with severe degenerative arthrit...

A novel in vitro model based on a solution mainly composed of sodium, calcium, chloride and phosphate ions, was developed to study the calcification of biomaterials at near physiological conditions. This model, due to its ability to quickly calcify the tested materials, is called Accelerated Calcification Solution (ACS). PolyactiveTM 30170, PolyactiveTM 70/30 and its composites with nano-apatit...