The GlnK and PII signal transduction proteins are paralogues that play distinct roles in nitrogen regulation. Although cells lacking GlnK appear to have normal nitrogen regulation, in the absence of PII, the GlnK protein controls nitrogen assimilation by regulating the activities of the PII receptors glutamine synthetase adenylyltransferase (ATase) and the kinase/phosphatase nitrogen regulator ...

A scheme for construction of uncertainty relations (UR) for n observables and m states is presented. Several lowest order UR are displayed and briefly discussed. For two states |ψ〉 and |φ〉 and canonical observables the (entangled) extension of Heisenberg UR reads [∆p(ψ)][∆q(φ)]+[∆p(φ)][∆q(ψ)] ≥ 1/2. Some possible applications of the new inequalities are noted.

OBJECTIVES This study aimed to evaluate the efficacy of gemcitabine-based chemoradiotherapy followed by surgery (gem-CRTS) for pancreatic ductal adenocarcinoma (PDAC) for borderline resectable (BR) and locally unresectable (UR) tumors. METHODS One hundred patients with PDAC who underwent the gem-CRTS protocol were classified into 3 groups, namely, resectable (R; 14), BR (44), and UR (42). Aft...

BACKGROUND Since the mid-2000s synthetic cannabinoids have been abused as recreational drugs, prompting scheduling of these substances in many countries. To circumvent legislation, manufacturers constantly market new compounds; [1-(5-fluoropentyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone (XLR-11), the fluorinated UR-144 analog, is one of the most recent and widely abused drugs, and ...

blink reactions, reduced response to the unconditioned stimulus (US) after repeated pairing of a conditioned stimulus (CS) with the US has been frequently observed (Baxter, 1966; Kimmel, 1967; Kimmel & Pennypacker as described in Kimmel, 1966). This phenomenon has been called «conditioned diminution of the unconditioned response (UR)» (Kimble & Ost, 1961), and a range of explanations have been ...

Using a function algebra characterization of exponential time due to Monien 5], in the style of Bellantoni-Cook 2], we characterize exponential time functions of linear growth via a safe course-of-values recursion scheme.

This article is a critical review of some of the methods that have been used for the sampling, analysis, and monitoring of vapor-phase toluene diisocyanate (TDI). Only some of the methods that have received relatively widespread application have been addressed in this article. This review includes a "tutorial style" discussion of basic definitions and basic principles and procedures of quality ...

BACKGROUND The ultrarush protocol is an attractive approach in the buildup phase of venom immunotherapy (VIT-UR). However, the degree of risk of VIT-UR in children remains unknown. The objective of this study was to compare the safety of VIT-UR in children and adults. METHODS We performed a study based on prospectively gathered medical records of children and adults with hymenoptera venom all...