Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed th...

An experiment was conducted to evaluate the additional effects of two ground medicinal herbs oat bran (OB) and dill seed (DS) on serum lipids, carcass characteristics and growth performance in Japanese quails. A total of 240-twenty one day of age male Japanese quails were allocated randomly to 3 treatments with 4 replicates of 20 birds per cage. Birds during the 22-49 days on trial received 3 d...

Jay C. Erickson et al. (1) describe the energy intake and energy expenditure of mutant obese mice (ob/ob) in which the gene for neuropeptide Y (NPY) is disrupted. They conclude that deficiency of NPY in the ob/ob mouse reduces the elevated food intake and increases the low energy expenditure, partially ameliorating the obesity. Another report, by Mary Ann Pelleymounter et al. (2), describes ene...

OBJECTIVE Hepatic steatosis is strongly associated with insulin resistance, but a causal role has not been established. In ob/ob mice, sterol regulatory element binding protein 1 (SREBP1) mediates the induction of steatosis by upregulating target genes, including glycerol-3-phosphate acyltransferase-1 (Gpat1), which catalyzes the first and committed step in the pathway of glycerolipid synthesis...

In order to examine the influence of obesity on metabolic disorder and liver pathogenesis of the Fatty Liver Shionogi (FLS) mouse, which develops hereditary fatty liver and spontaneous liver tumors, we established a new congenic strain named FLS-Lep(ob). The Lep(ob) gene of the C57BL/6JWakShi (B6)-Lep(ob)/Lep(ob) mouse was transferred into the genome of the FLS mouse, by backcross mating. FLS-L...