Background Nucleus basalis of Meynert (NbM) is the main source cholinergic projection to cerebral cortex, including entorhinal cortex (EC). Both cells NbM and their receptive targets in EC show degeneration during early stages Alzheimer’s disease (AD). While precise delineation region on T1w scans difficult due limited spatial resolution contrast, we sought quantify along trajectory confirm rec...

Rats with electrolytic lesions of the nucleus basalis magnocellularis were compared to sham-lesioned rats in the retention of a continuously reinforced lever-pressing response and in the acquisition and reversal of a visual discrimination task. The muscarinic agonist pilocarpine, in conjunction with the peripheral muscarinic antagonist methyl-scopolamine, was administered in three doses to subs...