Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown connection between periodontal disease and cardiovascular as oxidative stress plays an important role in chronic inflammatory diseases such disease. Nuclear factor erythroid 2 - related (Nrf2) core transcriptional regulator endogenous antioxidant system cellular defe...

The transcription factor nuclear factor erythroid-2 is over-expressed in patients with myeloproliferative neoplasms irrespective of the presence of the JAK2(V617F) mutation. Our transgenic mouse model over-expressing nuclear factor erythroid-2, which recapitulates many features of myeloproliferative neoplasms including transformation to acute myeloid leukemia, clearly implicates this transcript...

The Nrf1 (Nuclear factor E2-related factor 1) transcription factor performs a critical role in regulating cellular homeostasis. Using a proteomic approach, we identified Host Cell Factor-1 (HCF1), a co-regulator of transcription, and O-GlcNAc transferase (OGT), the enzyme that mediates protein O-GlcNAcylation, as cellular partners of Nrf1a, an isoform of Nrf1. Nrf1a directly interacts with HCF1...

Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined whether rifampicin exhibits beneficial effects mediated by the Nrf2 pathway after g...

Osteoarthritis (OA) is one of the most common degenerative joint diseases associated with aging, obesity and trauma, always pain, deformity dysfunction. Recent studies have shown that OA closely related to oxidative stress, which serves as a major cause chronic inflammation in cartilage, leading irreversible structural changes joint. As transcription factor, nuclear factor erythroid 2-related 2...