Studies demonstrated that reduced PTEN levels are associated with poor prognoses of osteosarcoma. The nuclear localization of PTEN is important for its tumor suppressive function. Equally importantly, PTEN is the most significant negative regulator of PI3K/Akt signaling cascade, the constitutively activated pathway in osteosarcoma. In our study MG63 cells and U2OS cells were treated with the in...

In high-energy transport codes used to design Accelerator Driven Systems or spallation neutron sources, elementary interactions are computed through nuclear physics models. Among these, Intra-Nuclear Cascade models play a major role since the excitation energy at the end of the INC stage determines the number of evaporated particles. Therefore, in simulation of spallation targets, INC influence...

New results from NA49 on the production of strangeness in elementary and nuclear reactions are presented. New measurements of charged kaon and pion production have been obtained from 40 AGeV Pb+Pb collisions. The evolution of strange meson yields in nucleus-nucleus interactions is studied as a function of collision energy and system size. Cascade baryon yields are presented for a wide range of ...

In this paper I calculate the anisotropic ux of cascade radiation produced by an isotropic distribution of highly relativistic protons immersed in the photon eld of a spatially separated point source. Most radiation is produced towards the source of the target photons. An astrophysical application of this result is X-ray irradiation of AGN accretion disks by highly dissipative nuclear jets. Low...

The early host response to viral infections involves transient activation of pattern recognition receptors leading to an induction of inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Subsequent activation of cytokine receptors in an autocrine and paracrine manner results in an inflammatory cascade. The precise mechanisms by which viruses avert an inflamm...

Acute pancreatitis is a major complication of endoscopic retrograde cholangiopancreatography (ERCP), its incidence varying with the indications for the procedure (<5% for the management of common bile duct stones and up to 20% in the case of sphincter of Oddi dysfunction) and also with events occurring during the ERCP such as acinarization and pancreatic sphincterotomy. If the triggering event ...

Apoptosis is a physiological, conserved program of cellular suicide, characterized by nuclear condensation, DNA-fragmentation and release of mitochondrial cytochrome c into the cytoplasm. The apoptotic program is executed by a cascade of highly specific caspases. The occurrence and significance of apoptosis in multinucleated, differentiated cells, like skeletal muscle cells is discussed controv...

We analyze the design of the target for pion production and energy deposition for the muon-muon collider using the nuclear cascade codes. Heat removal from high-energy deposition in the target is discussed, together with the use of a target compressed by a laser, or lightand heavyions drivers. The latter approach needs further technological development, but it can reduce substantially the energ...

The transcription factor FoxO1 links the phosphatidylinositol 3-kinase (PI 3-kinase) --> Akt cascade to gene expression that regulates cell growth, survival, and metabolism. The receptors for insulin and IGFs factors are linked to this pathway through tyrosine phosphorylation of insulin receptor substrates-Irs1, 2, 3, and 4. However, it is unclear why Irs2 signaling predominates in certain tiss...

The focus of our center is to design, prepare, and investigate novel fluorescent probes, termed “through-bond energy transfer cassettes”, for intracellular imaging. At this stage, it involves chemical syntheses of the probes (Burgess), conjugation to proteins involved in a signaling cascade for nuclear localization, and observation in cells, both under conventional conditions (Schroeder) and on...