Methods for mass producing bacterial alginate, bacterial cultures for producing alginate, and pharmaceutical compositions containing bacterial alginate are contemplated. Inventors: YU; Hongwei D.; (Huntington, WV) ; Qiu; Dongru; (Norman, OK) ; Damron; F. Heath; (Huntington, WV) Assignee: Marshall University Research Corporation Huntington WV Serial No.: 432474 Series Code: 12 Filed: April 29, 2...

The present paper reports the design and preparation of an amphiphilic triblock co-polymer poly(ε-caprolactone) (PCL)-poly(6,14-dimethyl-1,3,9,11-tetraoxa-6,14-diaza-cyclohexadecane-2,10-dione) (PADMC)-PCL and the use of micelles composed of them as carriers for pH-sensitive drug release. The triblock co-polymers were synthesized via two-step ring-opening polymerization with catalysis by Novozy...

4,560,665 A 4,943,522 A 4,965,211 A 5,124,268 A 5,792,330 A 5,830,769 A 5,876,960 A 6,136,549 A 6,242,268 B1 6,569,630 B1 6,599,715 B1 2002/0135772 A1 2003/0064427 A1 2003/0138876 A1 2004/0014154 A1 12/ 1985 7/1990 10/1990 6/1992 8/1998 11/1998 3/1999 10/2000 6/200 1 5/2003 7/2003 9/2002 4/2003 7/2003 1/2004 Nakae et al. ............... 436/172 Eisinger et al. ............ 435/7.25 Wieder et al...

Overexpression of the c-erbB-2 gene-encoded p185 has been reported in approximately 30% of human breast cancers and has been correlated with lymph node metastasis and poor prognosis in breast cancer patients. To investigate whether overexpression of p185 can enhance the metastatic potential of human breast cancer cells, we have introduced the human c-erbB-2 gene into the very low p185-expressin...

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BACKGROUND/AIMS Until recently, the cell line MDA-MB-435 was widely accepted as originating from a breast cancer. However, microarray derived data have suggested that this cell line may in fact originate from an occult melanoma. This study was designed to investigate this hypothesis further. METHODS Quantitative reverse transcription polymerase chain reaction and immunohistochemistry were use...

Several molecules that suppress metastasis without suppressing tumorigenicity have been identified, but their mechanisms of action have not yet been determined. Many block growth at the secondary site, suggesting involvement in how cells respond to signals from the extracellular milieu. Breast cancer metastasis suppressor 1 (BRMS1)-transfected MDA-MB-435 cells were examined for modifications of...

The origin of cell lines is critical in defining cell type-specific biological functions. Several reports suggested that the MDA-MB-435 cell line, a cell line extensively used for studying breast cancer biology, has a gene expression pattern most compatible with melanocyte origin. However, we demonstrate that MDA-MB-435 cells express breast-specific or epithelial-specific markers. Also, MDA-MB-...

(54) POLYAMIDES FOR NUCLEICACID CI2N IS/II (2006.01) DELIVERY A 6LX 3L/705 (2006.01) C7H 2L/04 (2006.01) (76) Inventor: Theresa M. Reineke, Blacksburg, C08G 69/48 (2006.01) VA (US) C08G 63/9. (2006.01) C7H 2L/02 (2006.01) Correspondence Address: A63L/7II (2006.01) DINSMORE & SHOHL, LLP CI2N IS/00 (2006.01) 1900 CHEMED CENTER, 255 EAST FIFTH A63L/7088 (2006.01) STREET CINCINNATI, OH 45202 (US) (...

The nanostructures and hydrophobic properties of cancer cell membranes are important for membrane fusion and cell adhesion. They are directly related to cancer cell biophysical properties, including aggressive growth and migration. Additionally, chemical component analysis of the cancer cell membrane could potentially be applied in clinical diagnosis of cancer by identification of specific biom...