BACKGROUND Small caliber vascular prostheses are not clinically available because synthetic vascular prostheses lack endothelial cells which modulate platelet activation, leukocyte adhesion, thrombosis, and the regulation of vasomotor tone by the production of vasoactive substances. We developed a novel method to create scaffold-free tubular tissue from multicellular spheroids (MCS) using a "Bi...

An innovative 3D multi-branch tubular structure and centerline extraction method is proposed in this paper. In contrast to classical minimal path techniques that can only detect a single curve between two pre-defined initial points, this method propagates outward from only one initial seed point to detect 3D multi-branch tubular surfaces and centerlines simultaneously. First, instead of only re...

Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression of RTN1A and ER stress markers was significantly increased in kidney biopsies of hyperuricemia patients with k...

Novel digital technologies always lead to high density and very low power consumption. One of these concepts is Quantum-dot Cellular Automata (QCA), which is one of the new emerging nanotechnology-based on Coulomb repulsion. This article presents three architectures of logical “XOR” gate, a novel structure of two inputs “XOR” gate, which is used as a module to implement four inputs “XOR” gate a...

The results of knowledge discovery in databases could vary depending on the data mining method. There are several ways to select the most appropriate data mining method dynamically. One proposed method clusters the whole domain area into “competence areas” of the methods. A metamethod is then used to decide which data mining method should be used with each database instance. However, when knowl...

We summarize the results of several experiments in applying a metamethod for formal method integration [18, 19]. We provide a small example of using an instance of integrated formal methods, and discuss properties and difficulties associated with applying the meta-method to combining and using several formal and semiformal methods.

Amelogenesis imperfecta (AI) is a heterogeneous group of inherited dental enamel defects. It has rarely been reported in association with multiorgan syndromes and metabolic disorders. The metabolic disorders that have been reported in association with AI include hypocalciuria, impaired urinary concentrating ability, and Bartter-like syndrome. In literature, only three cases of AI and distal ren...

Background & Objectives: Tubular adenomas are rare benign epithelial tumours of breast affecting predominantly females of child bearing age group. Till now, very small number of cases have been reported in the literature. Present study was carried out to evaluate the clinico-pathological features of tubular adenoma cases diagnosed during three years study period along with discussion of possibl...

In the paper titled " Endolymphatic Sac Enlargement in a Girl with a Novel Mutation for Distal Renal Tubular Acidosis and Severe Deafness, " all the authors' names and surnames are in a reverse order.

Our aim was to optimize a SOA control system by evolving the architecture of the service component that transforms system models into task trees, which are then executed by the runtime library called the Task Tree Executor, TTE. In the paper we present the two novel TTE architectures that evolved from the previous TTE architecture and introduced finer grained parallelism. The novel architecture...