نتایج جستجو برای: novel anticancer agent

تعداد نتایج: 1047481  

Journal: :Chemical science 2016
Ryan J Beattie Thomas W Hornsby Gemma Craig M Carmen Galan Christine L Willis

A de novo approach for the rapid construction of orthogonally protected l- and d-deoxysugars and analogues is described. A novel and robust silicon-acetal undergoes Prins cyclisations with a series of homoallylic alcohols in high yield and excellent stereocontrol. Modified Tamao-Fleming oxidation of the resulting silyltetrahydropyrans gives direct access to deoxyglycoside analogues and the appr...

Journal: :Chemical communications 2014
Masataka Togashi Takuya Terai Hirotatsu Kojima Kenjiro Hanaoka Kazuei Igarashi Yasunobu Hirata Yasuteru Urano Tetsuo Nagano

Acrolein, a cytotoxic α,β-unsaturated aldehyde and disease biomarker, was determined in plasma by means of a novel tethering strategy using Michael addition of the compound to a fluorescent dye, followed by immobilization of the product on microbeads via the aldehyde moiety. Elevation of blood acrolein was detected in mice treated with an anticancer agent cyclophosphamide, which releases acrole...

2016
Ryan J. Beattie Thomas W. Hornsby Gemma Craig M. Carmen Galan Christine L. Willis

A de novo approach for the rapid construction of orthogonally protected Land D-deoxysugars and analogues is described. A novel and robust silicon-acetal undergoes Prins cyclisations with a series of homoallylic alcohols in high yield and excellent stereocontrol. Modified Tamao–Fleming oxidation of the resulting silyltetrahydropyrans gives direct access to deoxyglycoside analogues and the approa...

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