نتایج جستجو برای: notch1

تعداد نتایج: 3350  

2016
Catia Giovannini Manuela Minguzzi Filippo Genovese Michele Baglioni Alessandra Gualandi Matteo Ravaioli Maddalena Milazzo Simona Tavolari Luigi Bolondi Laura Gramantieri

Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide amongst all human cancers causing one million deaths annually. Despite many promising treatment options, long-term prognosis remains dismal for the majority of patients who develop recurrence or present with advanced disease. Notch signaling is an evolutionarily conserved pathway crucial for the development and homeostasis of man...

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Journal: :Molecular cell 2012
Ahmad Yatim Clarisse Benne Bijan Sobhian Sabine Laurent-Chabalier Olivier Deas Jean-Gabriel Judde Jean-Daniel Lelievre Yves Levy Monsef Benkirane

Activating mutations in NOTCH1, an essential regulator of T cell development, are frequently found in human T cell acute lymphoblastic leukemia (T-ALL). Despite important advances in our understanding of Notch signal transduction, the regulation of Notch functions in the nucleus remains unclear. Using immunoaffinity purification, we identified NOTCH1 nuclear partners in T-ALL cells and showed t...

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2015
Mariya T. Sweetwyne Antje Gruenwald Thiruvur Niranjan Ryuichi Nishinakamura Lothar J. Strobl Katalin Susztak

Notch pathway activation in podocytes has been shown to play an important role in diabetic kidney disease (DKD) development; however, the receptors and ligands involved in the process have not been identified. Here, we report that conditional deletion of Notch1 in podocytes using NPHS2(cre)Notch1(flox/flox) animals resulted in marked amelioration of DKD. On the contrary, podocyte-specific genet...

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2017
Libin Ma Kean Chen Kang Jiang Gang Deng Peiwu Jiang Jia Shao Zhijian Yu

Emodin exhibits anti-proliferative effects in numerous cancer cell lines via different mechanisms. The present study aimed to study the effects and underlying molecular mechanisms of emodin on bladder cancer cells. We treated two bladder cancer cell lines, T24 and 5637, with different concentrations of emodin (20, 40 and 80 μmol/L) or DMSO (Control). We analyzed the biological effects of emodin...

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Journal: :Haematologica 2012
Ilaria Del Giudice Davide Rossi Sabina Chiaretti Marilisa Marinelli Simona Tavolaro Sara Gabrielli Luca Laurenti Roberto Marasca Silvia Rasi Marco Fangazio Anna Guarini Gianluca Gaidano Robin Foà

Trisomy 12, the third most frequent chromosomal aberration in chronic lymphocytic leukemia (CLL), confers an intermediate prognosis. In our cohort of 104 untreated patients carrying +12, NOTCH1 mutations occurred in 24% of cases and were associated to unmutated IGHV genes (P=0.003) and +12 as a sole cytogenetic abnormality (P=0.008). NOTCH1 mutations in +12 CLL associated with an approximately ...

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Journal: :Cancer discovery 2014
Alexander Stoeck Serguei Lejnine Andrew Truong Li Pan Hongfang Wang Chongzhi Zang Jing Yuan Chris Ware John MacLean Philip W Garrett-Engele Michael Kluk Jason Laskey Brian B Haines Christopher Moskaluk Leigh Zawel Stephen Fawell Gary Gilliland Theresa Zhang Brandon E Kremer Birgit Knoechel Bradley E Bernstein Warren S Pear X Shirley Liu Jon C Aster Sriram Sathyanarayanan

UNLABELLED Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with high levels of activated NOTCH1 (N1-ICD) were sensitive to the gamm...

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Journal: :Development 2000
A Zine T R Van De Water F de Ribaupierre

The development of the mammalian cochlea is an example of patterning in the peripheral nervous system. Sensory hair cells and supporting cells in the cochlea differentiate via regional and cell fate specification. The Notch signaling components shows both distinct and overlapping expression patterns of Notch1 receptor and its ligands Jagged1 (Jag1) and Jagged2 (Jag2) in the developing auditory ...

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2016
Ying Li Evangeline Tzatzalos Kelvin Y. Kwan Martin Grumet Li Cai

Notch1 signaling plays a critical role in maintaining and determining neural stem/progenitor cell (NSPC) fate, yet the transcriptional mechanism controlling Notch1 specific expression in NSPCs remains incomplete. Here, we show transcription factor Nkx6.1 interacts with a cis-element (CR2, an evolutionarily conserved non-coding fragment in the second intron of Notch1 locus) and regulates the exp...

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Journal: :Blood 2009
Leah J Anderson Richard Longnecker

Expression of latent membrane protein 2 (LMP2A) during B-cell development leads to global alterations in gene transcription similar to those seen in Hodgkin Reed-Sternberg cells of Hodgkin lymphoma (HL). Along with the consistent detection of LMP2A in Epstein-Barr virus-associated HL, this implicates a role for LMP2A in the pathogenesis of HL. We have shown that LMP2A constitutively activates t...

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2010
Yucel Erbilgin Muge Sayitoglu Ozden Hatirnaz Omer Dogru Arzu Akcay Gulen Tuysuz Tiraje Celkan Gonul Aydogan Zafer Salcioglu Cetin Timur Lebriz Yuksel-Soycan Umit Ure Sema Anak Leyla Agaoglu Omer Devecioglu Inci Yildiz Ugur Ozbek

The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T-ALL patients. In this study, the mutation analysis ...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->