Resident Medical Officer, Police Hospital, Calcutta. The; following is a case of cephalic tetanus (Kaf. tetanus of Rose) originating without any visible wound, characterised by stiffness of neck, trunk and limb muscles, without involvement of the jaw or any paralysis of the facial muscles. There was difficulty in swallowing and regurgitation through the nostrils on account of spasms affecting t...

Worldwide, an estimated 2 billion healthy people carry Staphylococcus aureus (SA) and of these, up to 53 million are thought to carry Methicillin Resistant Staphylococcus aureus (MRSA). SA is a feared pathogen because it causes severe infections and spread by metastatic foci. SA commonly colonizes the nostrils, skin, perineum, respiratory tract, open wounds and urinary tract which serves potent...

BACKGROUND This article presents long-term outcomes after correcting secondary bilateral cleft lip nasal deformities using a refined reverse-U incision and V-Y plasty or in combination with a composite graft in order to elongate the short columella. METHODS A total of forty-six patients underwent surgery between September 1996 and December 2008. The age of the patients ranged from 3 to 19 yea...

BACKGROUND Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; <100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb. METHODS To determine if olfactory translocation occurs for other solid metal UFPs and assess potential health effects, we exposed groups of rats to mangane...

BACKGROUND Aspergillus fumigatus is the most prevalent airborne fungal pathogen, and the ribotoxin Asp f 1 is one of its major allergens. Alpha-Sarcin is a natural variant of Asp f 1 produced by the nonpathogenic fungus Aspergillus giganteus. Both proteins show a sequence identity of 87% and almost identical 3-dimensional structures. Alpha-Sarcin delta(7-22) is a deletion mutant that displays r...

Nasal potential difference (NPD) is used as a biomarker of the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) activity. We evaluated methods to detect changes in chloride and sodium transport by NPD based on a secondary analysis of a Phase II CFTR-modulator study. Thirty-nine subjects with CF who also had the G551D-CFTR mutation were randomized t...

OBJECTIVE To characterize the nasal opening of the human nasopalatine duct (NPD; a major duct of the vomeronasal system used in animals for chemical communication) by identifying its location, categorizing variations in physical characteristics, and assessing frequency of detection. DESIGN Two studies: (1) general study incorporating endoscopic examinations documented by videotapes and photog...

Patients with a paranasal disorder often manifest voice change. Yet, computer simulation of these nasal sounds is difficult using a nasal tract model without any branching cavity. In other words, acoustic property of the nasal tract is influenced by a coupling with the paranasal sinuses. If the transfer function of the sinus acts as a Helmholtz resonator, the resonance frequency, or "zero" poin...

Ayurveda is one of the most renowned traditional systems medicine that has survived and flourished from ages till date. There are many avenues still to be explored by researchers, practitioners experts in field who carry responsibility keeping alive contributing their growth future. Panchakarma a fivefold treatment modality used for detoxification body preventive, curative as well rejuvenative ...