N-acetyl-dinaline (CI-994) is an investigational anti-cancer drug which inhibits histone deacetylases. We evaluated the interaction between CI-994 and conventional chemotherapeutics used in acute myeloid leukemia (AML) in a rat model for AML and Brown Norway rat acute myelocytic leukemia (BNML). In vitro, CI-994 in combination with cytarabine (ara-C), daunorubicin and mitoxantrone, resulted in ...

Norway rats were eradicated on bush-covered Hawea Island (9 ha) in Breaksea Sound, using the anticoagulant rodenticide "Talon 50 WB" (brodifacoum). The work was done as a conservation measure and to evaluate the feasibility and costs of eradicating rodents quickly from islands. The 50-100 rats present were eradicated in about two weeks by applying a simple strategy that took full account of the...

The Norway rat (Rattus norvegicus) was the first mammal to be domesticated primarily for research purposes, perhaps as many as 150 yr ago. The rat is 1 of the 2 most widely used experimental animals in biomedical research; and a wealth of knowledge, primarily in physiology, is available (Jacob and others 1995; James and Lindpaintner 1997). Many genetically defined strains have been developed an...

In LEW rats treated daily with variable doses of FK506 for 14 days and weekly thereafter, successful intestinal transplantation from fully allogeneic BN donors never was complicated by fatal GVHD. In contrast, with LEW-to-BN transplantation, rejection was difficult to control and GVHD developed after the end of the daily treatment. However, FK506 in high daily doses continued after the initial ...

Address: 1Norwegian Air Ambulance Foundation, Department of Research, Drøbak, Norway, 2Department of Surgery, Stavanger University Hospital, Norway, 3Department of Surgical Sciences, University of Bergen, Norway, 4Department of Orthopaedic Surgery, Stavanger University Hospital, Norway, 5Faculty of Medicine, Faculty Division Ullevål University Hospital, University of Oslo, Norway and 6Trauma Un...

Reply to comment: Month of birth and risk of multiple sclerosis: confounding and adjustments Øivind Torkildsen*, Jan Aarseth, Elisabeth Gulowsen Celius, Trygve Holmøy, Margitta T. Kampman, Kristin Ingeleiv Løken-Amsrud, Rune Midgard, Kjell-Morten Myhr, Trond Riise & Nina Grytten Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norwa...

Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, N-9038 Tromsø, Norway; Department of Medical Microbiology, Drammen Hospital, Drammen, Norway; Department of Medicine, Drammen Hospital, Drammen, Norway; Laboratory for Medical Microbiology, Levanger Hospital, Levanger, Norway; Research Group for Host...

Address: 1Department of Research and Development, Norwegian Air Ambulance Foundation, Drobak, Norway, 2Faculty of Medicine, Faculty Division Ulleval University Hospital, University of Oslo, Norway, 3Department of Anaesthesiology, Aker University Hospital, Oslo, Norway, 4Department of Anaesthesiology and Emergency Medicine, St Olav University Hospital, Trondheim, Norway, 5Prehospital division, U...