Abstract AIMS Glioblastomas (GBMs) are characterised by highly hypoxic regions and the ability to invade into healthy brain tissue promoting tumour dissemination recurrence; development of novel anti-migratory inhibitors target cell invasion recurrence must consider varying treatment responses in this background. As proof principle we investigated activity two, previously characterised, small m...

The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The HIFα subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. We confirmed that TNBC cells secrete glutamate, which we found is both necessary and sufficient for the paracrine ...

Arachidonic acid (AA) is released from cells after nervous tissue injuries.We treated rat cortical neurons and astrocytes cultured under normoxic or simulated ischemic conditions with N-acetylcysteine (100 or 200 microM) or ebselen (10 or 20 microM). N-acetylcysteine decreased AA release in normoxic astrocytes, while ebselen decreased AA release from astrocytes in both conditions. N-acetylcyste...

introduction: polymer gels are modern dosimeters providing three dimensional dose distributions. these dosimeters can be used in brachytherapy in which the tumor dimension is relatively small and the dose gradient is high. in this study, the ability of the magica polymer gel was investigated for assessing the absolute dose values as well as the dose distribution of low dose rate (ldr) ir-192 wi...

Myocardial infarction (MI) activates the epicardium to form epicardial stromal cells (EpiSC) that reside in hypoxic microenvironment. Paracrine factors secreted by EpiSC were shown modulate injury response of post-MI heart and improve cardiac function. We have previously reported expression angiogenic cytokines vascular endothelial growth factor A (VEGFA) IL-6 is strongly upregulated adenosine ...