Generalized additive models (GAMs) have been widely used. While the procedure for fitting a generalized additive model to independent data has been well established, not as much work has been done when the data are correlated. The currently available methods are not completely satisfactory in practice. A new approach is proposed to fit generalized additive models with spatio-temporal data via t...

The experience of our self-help organisation shows that the reason patients with symptoms of magnesium (Mg) deficiency do not get Mg therapy is acceptance of an inappropriate lower limit of the reference values for serum Mg concentration. The commonly designated low limit of the normal range seems to have been selected from values obtained for symptomatic patients. It is below levels that exist...