Background: With the spread of nanotechnology, various nanoparticles with new and emerging properties have been produced and the potential toxic effects of the majority of these particles remains still unknown. The present study was conducted to determine the toxicity of Molybdenum Trioxide nanoparticles in blood and body tissues of male Wistar rats. Materials and Methods: Thirty Wistar rats w...

The purpose of this study was to determine the effects of diabetes mellitus and insulin resistance on semen parameters, histology of reproductive organs and serum concentrations of testosterone and luteinizing hormone (LH). Male Sprague-Dawley rats weighing 180 - 200g were made diabetic by intravenous injection of alloxan (40 mg/kg): and insulin resistant by chronic fructose feeding (25% fructo...

The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and beta-cell mass were examined in nondiabetic, insulin-resistant obese fa/fa Zucker rats. After 6 wk of treatment, ad libitum-fed exenatide-treated (EX) and pair-fed vehicle control (PF) rats had comparable food intake, body weight, hemoglobin A(1c) (HbA(1c)), and fasting plasma concentrati...

The male reproductive system is vulnerable to oxidative stress, which linked several disorders. Silibinin, a natural polyphenolic flavonoid, possesses antioxidant, anti-inflammation and anticancer properties. Considering silibinin's wide range of biological metabolic roles (silibinin) plays, the current study was conducted evaluate biochemical, histological, immunohistochemical morphometric cha...

background: royal jelly has been shown to have antioxidant and antidiabetic effects. the objective of this study was to evaluate the protective effect of rj against kidney damage in streptozotocin induced diabetic rats. methods: thirty two male wistar rats were divided randomly into four groups (n=8 per group). normal control and diabetic control groups received 1cc/day distilled water, normal ...

Background: Spermatogenesis associated 19 (Spata19) was introduced as a testis-specific gene that probably involved in spermatogenesis cell apoptosis. Therefore, this study aimed to investigate the effect of Spata19 inactivation on sperm count. Materials and Methods: We generated global knockout mice by CRISPR/Cas9 nickase technology. Disability validated three levels DNA, RNA, protein using PC...

BACKGROUND Obesity among young children in Hong Kong has become a public health problem. This study explored associations between Chinese parent reported children's quality of life (QoL), socio-demographics and young children's weight status from 27 preschool settings. METHODS A mixed-method approach, including quantitative and qualitative tools, was employed for this cross-sectional study. Q...

The greater cane rats (Thryonomys swinderianus) and African giant pouched rats (Cricetomys gambianus) are among the largest rodents in Africa, undergoing domestications for meat and research purposes. The aim of this study was to explore whether there are any quantitative anatomical gastrointestinal adaptations associated with their omnivorous or herbivorous diets. In the African giant rat, the...