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OBJECTIVE The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed. METHODS 118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of -1, 0, 1, 2 and 3 mm, respectively. Id...

Objective: Intensity modulated radiotherapy (IMRT) is an exciting new technique with the potential to improve radiotherapy treatment by reducing dose to normal structures and increasing dose to the cancer. The objective was to investigate the potential value of IMRT in the treatment of sarcoma. To compare normal tissue sparing and treatment volume coverage for both three dimensional conformal (...

Quantitative radiobiological models can be used to assess the optimum clinical outcome from sophisticated therapeutic modalities by calculating tumor control probability (TCP) and normal tissue complication probability (NTCP). In this study two 3D-CRT and an IMRT treatment plans were developed with an initial prescription dose of 60 Gy in 2 Gy/fraction to prostate. Sensitivity of TCP and Compli...

The probability for a complication after radiotherapy is usually a function of dose and volume in the organ or tissue of interest. In most epidemiological studies the risk for a complication is stratified in terms of dose, but not irradiated volume. We show that the obtained risk cannot generally be applied to radiotherapy patients.The epidemiological data of Darby et al. (N Engl J Med 368:2527...

Introduction In this article, we report the results of our investigation on comparison of radiobiological aspects of treatment plans with linear accelerator-based intensity-modulated radiation therapy and volumetric-modulated arc therapy for patients having hippocampal avoidance whole-brain radiation therapy. Materials and Methods In this retrospective study using the dose-volume histogram, w...

PURPOSE Mathematical models are used in Industrial & Systems Engineering to analyze complex integrated operational systems. Adapting this approach to radiation therapy can help quantify the precision and accuracy necessary to achieve optimal outcome of radiation treatment. The purpose of this work is to develop such a model using clinical data and assess the effect uncertainties have on treatme...